Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Natural killer cells in chronic leukemia. Function and markers.

D Sørskaar1, O Førre, P Stavem

  • 1Institute of Immunology and Rheumatology, National Hospital, Oslo, Norway.

International Archives of Allergy and Applied Immunology
|January 1, 1988
PubMed
Summary

Natural killer (NK) cell activity is significantly reduced in chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML) patients. This reduced NK cell activity may play a role in the development of these chronic leukemias.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The association of PTPN22 rs2476601 with juvenile idiopathic arthritis is specific to females.

Genes and immunity·2015
Same author

CIITA gene variants are associated with rheumatoid arthritis in Scandinavian populations.

Genes and immunity·2012
Same author

Endothelial function improves within 6 weeks of treatment with methotrexate or methotrexate in combination with a TNF-α inhibitor in rheumatoid arthritis patients.

Scandinavian journal of rheumatology·2012
Same author

Anti-CCP and RF IgM: predictors of impaired endothelial function in rheumatoid arthritis patients.

Scandinavian journal of rheumatology·2011
Same author

Chest abnormalities in juvenile-onset mixed connective tissue disease: assessment with high-resolution computed tomography and pulmonary function tests.

Acta radiologica (Stockholm, Sweden : 1987)·2009
Same author

A coding polymorphism in NALP1 confers risk for autoimmune Addison's disease and type 1 diabetes.

Genes and immunity·2008

Area of Science:

  • Immunology
  • Hematology
  • Oncology

Background:

  • Natural killer (NK) cells are crucial for immune surveillance against cancer.
  • Chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML) are characterized by uncontrolled proliferation of lymphocytes and myeloid cells, respectively.

Purpose of the Study:

  • To investigate natural killer (NK) cell activity and related cell markers in patients with CLL and CML.
  • To determine the potential role of reduced NK cell activity in the pathogenesis of these leukemias.

Main Methods:

  • Assessed NK cell activity and expression of Leu 7 and Leu 11b (CD 16) markers in peripheral blood and bone marrow of CLL and CML patients.
  • Utilized cell separation techniques to evaluate the impact of leukemic cell removal on NK activity.

Related Experiment Videos

Main Results:

  • Significantly reduced NK cell activity and lower numbers of Leu 7 and Leu 11b (CD 16) positive cells were observed in CLL patients.
  • NK cell activity in CLL bone marrow did not differ significantly from controls, suggesting leukemic cell overgrowth impacts peripheral NK activity.
  • Both chronic and advanced phase CML patients exhibited reduced NK activity, suggesting a potential inherent NK cell defect in CML.

Conclusions:

  • Reduced NK cell activity is a common feature in both CLL and CML.
  • Leukemic cell burden contributes to diminished NK activity in CLL.
  • An inherent NK cell defect may be present in CML, potentially contributing to disease development.