Related Experiment Video

Updated: Feb 11, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.7K

Pediatric Methicillin-Resistant Staphylococcus aureus Osteoarticular Infections

Ashlesha Kaushik1, Helen Kest2

  • 1Pediatric Infectious Disease, Unity Point Health and Siouxland Medical Education Foundation, 2720 Stone Park Blvd, Sioux City, IA 51104, USA. ashleshakaushik@gmail.com.

Microorganisms
|May 9, 2018
PubMed

Insights

Pediatric osteoarticular infections (OSI) are increasingly caused by methicillin-resistant Staphylococcus aureus (MRSA). Empiric treatment for pediatric OSI must include MRSA-effective antibiotics due to its prevalence and association with severe outcomes.

Area of Science:

  • Pediatric infectious diseases
  • Microbiology
  • Orthopedic surgery

Background:

  • Osteoarticular infections (OSI) pose significant challenges in pediatric patients, impacting growth and leading to long-term sequelae.
  • Methicillin-resistant Staphylococcus aureus (MRSA) has become a leading cause of pediatric OSI, necessitating specific treatment considerations.
  • The PVL-producing ST8/USA300 clone is a prevalent MRSA strain associated with community-onset disease and potentially more severe infections.

Purpose of the Study:

  • To review the pathogenesis, clinical spectrum, diagnosis, and management guidelines for MRSA-related pediatric OSI.
  • To highlight the importance of MRSA coverage in empiric antibiotic therapy for pediatric OSI.
  • To discuss methods for characterizing MRSA strains, including antimicrobial susceptibility testing and genetic typing.

Main Methods:

  • Review of existing literature on MRSA osteoarticular infections in children.
  • Analysis of diagnostic challenges and current management strategies.
  • Discussion of MRSA strain characterization techniques such as SCCmec typing and MLST.

Main Results:

  • MRSA is a predominant pathogen in pediatric OSI, requiring specific empiric antibiotic choices.
  • Certain MRSA clones, like ST8/USA300, are associated with widespread community-onset infections and potentially increased severity.
  • Effective management relies on early diagnosis, appropriate antibiotic selection, and understanding MRSA strain characteristics.

Conclusions:

  • Empiric antibiotic therapy for pediatric OSI should always include coverage for MRSA.
  • Understanding MRSA epidemiology and virulence factors, such as PVL, is crucial for effective treatment.
  • Adherence to current management guidelines and consideration of strain typing can improve outcomes for children with MRSA OSI.

Keywords:
childrenmethicillin-resistant Staphylococcus aureusosteoarticular infections

More Related Videos

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat

Published on: June 4, 2012

17.6K
Development and Assessment of Intracellular Infection Models for Staphylococcus aureus08:32

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

Published on: January 17, 2025

1.3K

Related Concept Videos

Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.0K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
274
Equivalent Resistance01:16

Equivalent Resistance

In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
998
Resistance and Conductance01:25

Resistance and Conductance

A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
527
Rolling Resistance01:21

Rolling Resistance

When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
675