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Association between Fas/FasL gene polymorphism and musculoskeletal degenerative diseases: a meta-analysis

Donghua Huang¹, Jinrong Xiao², Xiangyu Deng¹

¹Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 JieFang Avenue, Wuhan, 430022, China.

BMC Musculoskeletal Disorders

|May 9, 2018

Abstract

Background:

It was reported that Fas (rs1800682, rs2234767) and FasL (rs5030772, rs763110) gene polymorphism might be related to the risk of musculoskeletal degenerative diseases (MSDD), such as osteoarthritis (OA), intervertebral disc degeneration (IVDD) and rheumatoid arthritis (RA). However, data from different studies was inconsistent. Here we aim to elaborately summarize and explore the association between the Fas (rs1800682, rs2234767) and FasL (rs5030772, rs763110) and MSDD.

Methods:

Literatures were selected from PubMed, Web of Science, Embase, Scopus and Medline in English and VIP, SinoMed, Wanfang and the China National Knowledge Infrastructure (CNKI) in Chinese up to August 21, 2017. All the researches included are case-control studies about human. We calculated the pooled odds ratios (ORs) with 95% confidence intervals (95% CI) to evaluate the strengths of the associations of Fas (rs1800682, rs2234767) and FasL (rs5030772, rs763110) polymorphisms with MSDD risk.

Results:

Eleven eligible studies for rs1800682 with 1930 cases and 1720 controls, 6 eligible studies for rs2234767 with 1794 cases and 1909 controls, 3 eligible studies for rs5030772 with 367 cases and 313 controls and 8 eligible studies for rs763110 with 2010 cases and 2105 controls were included in this analysis. The results showed that the G allele of Fas (rs1800682) is associated with an increased risk of IVDD in homozygote and recessive models. The G allele of Fas (rs2234767) is linked to a decreased risk of RA but an enhanced risk of OA in allele and recessive models. In addition, the T allele of FasL (rs763110) is correlated with a reduced risk of IVDD in all of models. However, no relationship was found between FasL (rs5030772) and these three types of MSDD in any models.

Conclusions:

Fas (rs1800682) and FasL (rs763110) polymorphism were associated with the risk of IVDD and Fas (rs2234767) was correlated to the susceptibility of OA and RA. Fas (rs1800682) and Fas (rs2234767) are more likely to be associated with MSDD for Chinese people. FasL (rs763110) is related to the progression of MSDD for both Caucasoid and Chinese race groups. But FasL (rs5030772) might not be associated with any types of MSDD or any race groups statistically.

Insights

Gene variations in Fas (rs1800682, rs2234767) and FasL (rs5030772, rs763110) are linked to musculoskeletal degenerative diseases (MSDD). Specific polymorphisms increase the risk for intervertebral disc degeneration (IVDD), osteoarthritis (OA), and rheumatoid arthritis (RA).

Area of Science:

Genetics
Molecular Biology
Rheumatology

Background:

Fas (rs1800682, rs2234767) and FasL (rs5030772, rs763110) gene polymorphisms are implicated in musculoskeletal degenerative diseases (MSDD) like osteoarthritis (OA), intervertebral disc degeneration (IVDD), and rheumatoid arthritis (RA).
Previous studies yielded inconsistent results regarding the association between these gene polymorphisms and MSDD risk.

Purpose of the Study:

To comprehensively review and analyze the association between Fas (rs1800682, rs2234767) and FasL (rs5030772, rs763110) polymorphisms and the risk of MSDD.
To clarify the role of these specific gene variations in the development of OA, IVDD, and RA.

Main Methods:

A systematic literature search was conducted across major databases (PubMed, Web of Science, Embase, Scopus, Medline, VIP, SinoMed, Wanfang, CNKI) up to August 21, 2017.
Included studies were case-control studies involving human subjects.
Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to assess the strength of associations.

Main Results:

Analysis included 11 studies for rs1800682 (1930 cases/1720 controls), 6 for rs2234767 (1794 cases/1909 controls), 3 for rs5030772 (367 cases/313 controls), and 8 for rs763110 (2010 cases/2105 controls).
The G allele of Fas (rs1800682) was associated with increased IVDD risk (homozygote and recessive models).
The G allele of Fas (rs2234767) was linked to decreased RA risk but increased OA risk (allele and recessive models).
The T allele of FasL (rs763110) was correlated with reduced IVDD risk (all models).
No statistically significant association was found between FasL (rs5030772) and the studied MSDDs.

Conclusions:

Fas (rs1800682) and FasL (rs763110) polymorphisms are associated with IVDD risk.
Fas (rs2234767) polymorphism is correlated with the susceptibility to OA and RA.
These associations, particularly for Fas (rs1800682 and rs2234767), appear stronger in Chinese populations.
FasL (rs763110) is linked to MSDD progression in both Caucasian and Chinese populations.
FasL (rs5030772) shows no statistically significant association with any MSDD types or race groups.

Read full analysis

Keywords:

Fas/FasL polymorphism Intervertebral disc degeneration Musculoskeletal degenerative diseases Osteoarthritis Rheumatoid arthritis

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