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Pluronics modified liposomes for curcumin encapsulation: Sustained release, stability and bioaccessibility.
Zi-Ling Li1, Sheng-Feng Peng2, Xing Chen2
1State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, PR China; School of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, Jiangxi, PR China.
Food Research International (Ottawa, Ont.)
|May 9, 2018
Summary
Pluronics modification significantly enhances curcumin liposomes stability and bioaccessibility. This improves curcumin absorption, showing potential for nutraceutical and functional food applications.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Curcumin, a potent bioactive compound, suffers from poor stability and low bioavailability.
- Liposomes are promising carriers for curcumin, but their stability and absorption can be further improved.
Purpose of the Study:
- To evaluate pluronics (F127, F87, P85) as modifiers for curcumin liposomes.
- To enhance the stability and bioaccessibility of curcumin liposomes (cur-Lps).
Main Methods:
- Curcumin liposomes were prepared using thin film evaporation and dynamic high pressure microfluidization.
- Pluronics were used to modify curcumin liposomes (cur-pluronic-Lps).
- Characterization included particle size, polydispersity index, FTIR, XRD, in vitro release, stability, and simulated gastrointestinal studies.
Main Results:
- Pluronics modification resulted in smaller particle size and lower polydispersity index for cur-pluronic-Lps.
- Curcumin release was slower and cumulative release was lower from cur-pluronic-Lps compared to cur-Lps.
- Pluronics enhanced pH and thermal stability, and significantly improved in vitro curcumin absorption.
- Bioaccessibility order: cur-Lps < cur-F87-Lps < cur-P85-Lps < cur-F127-Lps.
Conclusions:
- Pluronics modification is a feasible strategy to improve curcumin liposome characteristics.
- Enhanced stability and bioaccessibility of pluronics-modified liposomes offer potential for curcumin delivery.
- These findings support the application of pluronics-modified liposomes in nutraceuticals and functional foods.
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