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Dynamic Functional Connectivity States Reflecting Psychotic-like Experiences.

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Psychotic-like experiences (PLEs) are linked to altered brain network dynamics, showing increased time in states with visual hyperconnectivity and default mode hypoconnectivity. This suggests neural dysfunction similar to psychotic disorders.

Keywords:
Default mode networkDynamic connectivityExecutive functionNetworkPsychosisPsychotic experiences

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Psychotic-like experiences (PLEs) are associated with impaired functioning and executive function.
  • Emerging evidence suggests PLEs reflect neural dysfunction akin to psychotic disorders.

Purpose of the Study:

  • To investigate dynamic functional brain connectivity in relation to PLEs.
  • To characterize network dysfunction in adults with PLEs using resting-state fMRI data.

Main Methods:

  • Analyzed resting-state fMRI data from the Human Connectome Project.
  • Utilized dynamic conditional correlation and k-means clustering to identify dynamic connectivity states.
  • Included 76 participants endorsing PLEs and 153 controls.

Main Results:

  • Identified three distinct dynamic brain connectivity states.
  • PLE-endorsing individuals spent more time in a state of visual hyperconnectivity and default mode network hypoconnectivity.
  • Worse executive function correlated with increased time and transitions into the hyperconnectivity state.

Conclusions:

  • PLEs are associated with altered large-scale brain dynamics.
  • Brain activity shifts towards states with visual hyperconnectivity and default mode hypoconnectivity in individuals with PLEs.
  • These findings suggest a neural basis for PLEs that resembles psychotic disorders.