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Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
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Association Between Psoriasis and Erectile Dysfunction: A Meta-Analysis.

Tao Wu1, Xi Duan2, Shulin Chen1

  • 1Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, People's Republic of China.

The Journal of Sexual Medicine
|May 9, 2018
PubMed
Summary
This summary is machine-generated.

Psoriasis is linked to a higher risk of erectile dysfunction (ED). This meta-analysis confirms a significant association, with psoriasis patients showing increased ED risk and lower sexual function scores.

Keywords:
Erectile DysfunctionMeta-AnalysisPsoriasisSexual Dysfunction

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Area of Science:

  • Dermatology
  • Urology
  • Public Health

Background:

  • Psoriasis is a chronic inflammatory disease with known associations to various comorbidities.
  • Previous studies suggest a link between psoriasis and erectile dysfunction (ED), but robust meta-analytic data were lacking.

Purpose of the Study:

  • To perform a comprehensive meta-analysis to quantify the association between psoriasis and the risk of developing ED.
  • To compare ED risk in psoriasis patients versus controls.

Main Methods:

  • Systematic literature search across major databases (MEDLINE, EMBASE, Cochrane, Google Scholar).
  • Pooled odds ratios (OR) and standardized mean difference (SMD) with 95% confidence intervals (CI) were calculated.
  • Included 9 studies comprising 36,242 psoriasis patients and 1,657,711 controls.

Main Results:

  • A statistically significant association was found between psoriasis and increased ED risk (OR 1.35; 95% CI 1.29-1.41).
  • Adjusted analyses also confirmed a significant association (OR 1.22; 95% CI 1.08-1.37).
  • Psoriasis patients exhibited significantly lower International Index of Erectile Function-5 scores (SMD -3.09; 95% CI -4.81 to -1.37).

Conclusions:

  • Psoriasis is associated with a significantly increased risk of erectile dysfunction.
  • Physicians should consider assessing ED risk in patients with psoriasis.
  • Further prospective studies are needed to confirm these findings and explore underlying mechanisms.