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Related Experiment Video

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Brucella Peptide Cross-Reactive Major Histocompatibility Complex Class I Presentation Activates SIINFEKL-Specific T

Jerome S Harms1,2, Mike Khan1,3, Cherisse Hall1

  • 1Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Infection and Immunity
|May 9, 2018
PubMed
Summary

Brucella bacteria can evade immune detection by presenting peptides that mimic host molecules. This molecular mimicry can activate T cells, potentially leading to chronic infections or autoimmune responses.

Keywords:
Brucella melitensisMHC-IT cell receptorchicken ovalbumincross-reactivitymajor histocompatibility complex class I

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Area of Science:

  • Immunology
  • Microbiology
  • Bacterial Pathogenesis

Background:

  • Brucella spp. are intracellular bacteria known for evading immune surveillance, causing chronic infections.
  • Understanding Brucella's immune evasion strategies is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the potential for T cell receptor (TCR) cross-reactivity to Brucella peptides.
  • To explore how Brucella might exploit T cell cross-reactivity for immune evasion.

Main Methods:

  • Engineered Brucella to express chicken ovalbumin (OVA) for immune studies.
  • Utilized OT-1 T cells (specific for OVA peptide SIINFEKL) in cytotoxicity assays.
  • Screened the Brucella proteome for peptides binding to H2Kb that mimic SIINFEKL.

Main Results:

  • OT-1 T cells recognized both OVA-expressing and parental Brucella-infected targets.
  • Splenocytes from Brucella-immunized mice showed reactivity to SIINFEKL-pulsed cells.
  • Several Brucella-derived peptides were identified that activate SIINFEKL-specific TCRs, demonstrating cross-reactivity.

Conclusions:

  • T cell cross-reactivity is a significant factor in host-pathogen interactions.
  • Brucella may use cross-reactive peptides to evade immune responses.
  • This phenomenon could contribute to both chronic infections and autoimmunity.