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Updated: Feb 11, 2026

High Resolution Physical Characterization of Single Metallic Nanoparticles
Published on: June 28, 2019
Physics of lumen growth
Sabyasachi Dasgupta1,2, Kapish Gupta1, Yue Zhang1
1Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.
Abstract:
We model the dynamics of formation of intercellular secretory lumens. Using conservation laws, we quantitatively study the balance between paracellular leaks and the build-up of osmotic pressure in the lumen. Our model predicts a critical pumping threshold to expand stable lumens. Consistently with experimental observations in bile canaliculi, the model also describes a transition between a monotonous and oscillatory regime during luminogenesis as a function of ion and water transport parameters. We finally discuss the possible importance of regulation of paracellular leaks in intercellular tubulogenesis.
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