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Updated: Feb 11, 2026
09:56
High Resolution Physical Characterization of Single Metallic Nanoparticles
Published on: June 28, 2019
6.2K
Physics of lumen growth
Sabyasachi Dasgupta1,2, Kapish Gupta1, Yue Zhang1
1Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.
Summary
This study models intercellular lumen formation, revealing a critical pumping threshold for stable lumen expansion. It explains how ion transport influences lumen dynamics, transitioning between steady and oscillatory states.
Area of Science:
- Cell Biology
- Biophysics
- Physiology
Background:
- Intercellular secretory lumens are crucial for tissue function.
- Understanding lumen formation dynamics is essential for developmental biology and disease research.
Purpose of the Study:
- To model the dynamics of intercellular secretory lumen formation.
- To quantitatively analyze the interplay between paracellular leaks and osmotic pressure.
- To predict conditions for stable lumen expansion and describe luminogenesis regimes.
Main Methods:
- Mathematical modeling using conservation laws.
- Quantitative analysis of fluid and solute transport.
- Parameter variation to explore different physiological conditions.
Main Results:
- A critical pumping threshold is identified for stable lumen expansion.
- The model predicts a transition from monotonous to oscillatory lumen formation based on transport parameters.
- Results are consistent with experimental observations in bile canaliculi.
Conclusions:
- Regulation of paracellular permeability is likely important for intercellular tubulogenesis.
- The model provides a quantitative framework for understanding lumen formation and its regulation.
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