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Thrombosis of the Portal Venous System in Cirrhotic vs. Non-Cirrhotic Patients

Vania Cruz-Ramón1, Paulina Chinchilla-López1, Oscar Ramírez-Pérez1

  • 1Liver Research Unit. Medica Sur Clinic & Foundation, Mexico City, Mexico.

Annals of Hepatology
|May 9, 2018
PubMed

Insights

Cirrhosis significantly increases the risk of portal venous system thrombosis, with hepatocellular carcinoma being a key factor. Non-cirrhotic patients with thrombosis often have extra-hepatic inflammatory conditions.

Area of Science:

  • Hepatology
  • Vascular Medicine
  • Radiology

Background:

  • Thrombosis is a serious liver vascular disorder.
  • Cirrhosis is a known risk factor for portal venous system thrombosis.
  • Understanding differences between cirrhotic and non-cirrhotic patients with thrombosis is crucial.

Purpose of the Study:

  • To identify differences in patients with portal venous system thrombosis.
  • To compare cirrhotic and non-cirrhotic individuals.
  • To evaluate the relationship between cirrhosis severity and thrombosis development.

Main Methods:

  • Retrospective study of 67 patients with portal venous system thrombosis (2012-2017).
  • Diagnosis confirmed by CT scan and Doppler ultrasound.
  • Patients classified into cirrhotic (n=42) and non-cirrhotic (n=25) groups.
  • Hepatic function assessed using Child-Pugh score and MELD score.

Main Results:

  • The cirrhotic group was older (65 vs 57 years) and had a higher incidence of portal vein thrombosis (64.29% vs 36%).
  • Extra-hepatic inflammatory conditions were present in 32% of non-cirrhotics but absent in cirrhotics.
  • Portal vein was the most common thrombosis site in both groups.

Conclusions:

  • Hepatocellular carcinoma and cirrhosis are primary risk factors for thrombosis in cirrhotic patients.
  • Extrahepatic inflammatory conditions are key risk factors in non-cirrhotic patients.
  • Portal vein thrombosis is prevalent in both cirrhotic and non-cirrhotic individuals.
Abstract

Keywords:
Cirrhosis. Portal vein. Thrombus. Predictive factor. Hepatocellular carcinoma.

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