Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Reproductive Cloning01:27

Reproductive Cloning

32.8K
Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
32.8K
Cloning of Dolly the Sheep01:08

Cloning of Dolly the Sheep

7.7K
The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter...
7.7K
Dynamic Equilibrium02:20

Dynamic Equilibrium

63.3K
A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
63.3K
Plant Tissue Culture02:57

Plant Tissue Culture

40.8K
Plant tissue culture is widely used in both primary and applied science. Applications range from plant development studies to functional gene studies, crop improvement, commercial micropropagation, virus elimination, and conservation of rare species.
40.8K
Sustainable Development01:43

Sustainable Development

15.2K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.2K
Seed Structure and Early Development of the Sporophyte02:33

Seed Structure and Early Development of the Sporophyte

31.3K
Seed structures are composed of a protective seed coat surrounding a plant embryo, and a food store for the developing embryo. The embryo contains the precursor tissues for leaves, stem, and roots. The endosperm and cotyledons—seed leaves—act as the food reserves for the growing embryo.
31.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The temporal architecture of the seminiferous epithelial cycle revealed by spatial transcriptomics.

Cell·2026
Same author

Early fibrotic niches establish tumour-permissive microenvironments.

Nature·2026
Same author

Comparative ASCL1 interactome analysis reveals CDK2-Cyclin A2 as suppressors of differentiation in MYCN-amplified neuroblastoma.

Molecular cancer research : MCR·2026
Same author

Cell stiffness regulates immune evasion during metastatic dormancy.

Nature cancer·2026
Same author

Human assembloids recapitulate periportal liver tissue in vitro.

Nature·2025
Same author

Neuroblastoma cell lines display heterogeneity in differentiation responses.

Wellcome open research·2025
Same journal

Simple input-output dependencies explain neuronal activity.

Nature physics·2026
Same journal

Scaling and self-similarity in the formation of the embryonic epigenome.

Nature physics·2026
Same journal

Adhesion-driven rigidity transition decoupled from density-driven jamming triggers epithelial organization in embryonic tissues.

Nature physics·2026
Same journal

The local mechanostructural properties of protein cargoes regulate nucleocytoplasmic transport.

Nature physics·2026
Same journal

Squeezing, trisqueezing and quadsqueezing in a hybrid oscillator-spin system.

Nature physics·2026
Same journal

Noise-induced shallow circuits and the absence of barren plateaus.

Nature physics·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

10.0K

Universality of clone dynamics during tissue development.

Steffen Rulands1,2,3,4,5, Fabienne Lescroart6, Samira Chabab6

  • 1Cavendish Laboratory, Department of Physics, JJ Thomson Avenue, University of Cambridge, Cambridge CB3 0HE, UK.

Nature Physics
|May 9, 2018
PubMed
Summary
This summary is machine-generated.

Cellular dynamics during organ development exhibit universal scaling behaviors, revealing insights into cell fate and non-equilibrium statistical physics. This study analyzes clone size evolution to understand complex biological systems.

More Related Videos

Robotics and Dynamic Image Analysis for Studies of Gene Expression in Plant Tissues
11:26

Robotics and Dynamic Image Analysis for Studies of Gene Expression in Plant Tissues

Published on: May 5, 2010

13.0K
Standardized Modular Assembly of Polycistronic Operons with Modular Cloning (MoClo) using the In-Cloning toolkit
06:28

Standardized Modular Assembly of Polycistronic Operons with Modular Cloning (MoClo) using the In-Cloning toolkit

Published on: September 2, 2025

846

Related Experiment Videos

Last Updated: Feb 10, 2026

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

10.0K
Robotics and Dynamic Image Analysis for Studies of Gene Expression in Plant Tissues
11:26

Robotics and Dynamic Image Analysis for Studies of Gene Expression in Plant Tissues

Published on: May 5, 2010

13.0K
Standardized Modular Assembly of Polycistronic Operons with Modular Cloning (MoClo) using the In-Cloning toolkit
06:28

Standardized Modular Assembly of Polycistronic Operons with Modular Cloning (MoClo) using the In-Cloning toolkit

Published on: September 2, 2025

846

Area of Science:

  • Developmental Biology
  • Statistical Physics
  • Cell Biology

Background:

  • Organ development relies on coordinated cell proliferation, migration, and differentiation.
  • Clonal tracing studies in adult tissues reveal cell fate but face challenges in developing organs due to tissue deformation.
  • Understanding clonal dynamics in development is crucial for deciphering organogenesis.

Purpose of the Study:

  • To investigate clonal dynamics during organ development.
  • To explore universal scaling behaviors in clone sizes despite tissue deformation.
  • To connect principles of statistical physics to cellular systems in development.

Main Methods:

  • Utilized results from clonal tracing studies.
  • Mapped clonal dynamics onto a generalized theory of aerosols.
  • Analyzed the time evolution of cell progeny (clones) as experimental observables.

Main Results:

  • Demonstrated that clonal dynamics in organ development can converge to a critical state.
  • Identified universal scaling behavior in clone sizes.
  • Elucidated the origin and range of these scaling behaviors.

Conclusions:

  • Universal scaling in clone sizes provides a framework for understanding complex organ development.
  • Statistical physics concepts, particularly non-equilibrium physics, are applicable to cellular systems.
  • This work offers methods to distill lineage-specific information from experimental data.