Related Experiment Video

Updated: Feb 10, 2026

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

975

Taxifolin attenuates diabetic nephropathy in streptozotocin-induced diabetic rats

Yanling Zhao1, Wenwen Huang1, Jiali Wang1

  • 1Department of Nephrology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325000, China.

American Journal of Translational Research
|May 9, 2018
PubMed

Insights

Taxifolin (TA) effectively mitigated diabetic nephropathy in rats induced by streptozotocin (STZ). This natural compound reduced blood glucose, kidney damage, and key biochemical markers, suggesting therapeutic potential for diabetes.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Nephrology

Background:

  • Diabetic nephropathy is a significant complication of diabetes mellitus.
  • Streptozotocin (STZ) is commonly used to induce diabetes in animal models for research purposes.
  • Identifying effective therapeutic agents for diabetic nephropathy is crucial.

Purpose of the Study:

  • To investigate the protective effects of taxifolin (TA) against streptozotocin (STZ)-induced diabetic nephropathy in a rat model.
  • To evaluate the impact of TA on key biochemical markers and kidney pathology associated with diabetes.

Main Methods:

  • Diabetic nephropathy was induced in rats using streptozotocin (STZ).
  • Oral glucose tolerance tests (OGTTs) and biochemical assays measured blood glucose, uric acid, creatinine, and serum insulin.
  • Kidney pathology was assessed using hematoxylin-eosin (H&E) staining, and Caveolin-1/NF-κB signaling was analyzed via qRT-PCR and western blotting.

Main Results:

  • Taxifolin (TA) significantly reduced blood glucose, uric acid, creatinine, and serum insulin levels in STZ-induced diabetic rats.
  • TA treatment alleviated pathological damage observed in the kidneys of diabetic rats.
  • TA restored the expression of Caveolin-1 and NF-κB signaling pathway components at both mRNA and protein levels.

Conclusions:

  • Taxifolin (TA) demonstrates significant nephroprotective effects in a rat model of STZ-induced diabetes.
  • The findings suggest that TA may exert its benefits by modulating the Caveolin-1/NF-κB signaling pathway.
  • TA shows potential as a therapeutic agent for mitigating diabetic nephropathy.
Keywords:
Caveolin-1NF-κBTaxifolininflammationstreptozotocin (STZ)

More Related Videos

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes05:18

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

5.9K
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

26.5K

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.7K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.1K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
506
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.4K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.1K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.5K