Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.5K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.5K
Common Ion Effect03:24

Common Ion Effect

47.0K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:
47.0K
Variability: Analysis01:11

Variability: Analysis

527
Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
527
Random Variables01:09

Random Variables

17.9K
A random variable is a single numerical value that indicates the outcome of a procedure. The concept of random variables is fundamental to the probability theory and was introduced by a Russian mathematician, Pafnuty Chebyshev, in the mid-nineteenth century.
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
For example, let X = the...
17.9K
Graphs of Equations in Two Variables01:30

Graphs of Equations in Two Variables

263
An equation with two variables, typically written in the form y = f(x) or Ax + By = C, describes a relationship between quantities represented by x and y. Each solution to such an equation is an ordered pair (x, y) that satisfies the equation when substituted. These pairs can be represented graphically to understand the variables' relationship visually.A common technique for constructing the graph of a two-variable equation is to create a value table. Begin by choosing several values for the...
263
Variables Affecting Phosphorescence and Fluorescence01:26

Variables Affecting Phosphorescence and Fluorescence

1.5K
Fluorescence and phosphorescence are essential phenomena in fields like analytical chemistry, biological imaging, and materials science, where they detect molecular properties and visualize cellular structures. Understanding the variables that influence these luminescent behaviors is crucial for maximizing accuracy and efficiency in their applications. These variables can broadly be grouped into chemical structure, solvent properties, and external conditions, each playing a distinct role in...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

VCAM-1 as a biomarker of early cardiac phenotypic changes in Fabry disease.

BMC cardiovascular disorders·2026
Same author

Urinary KIM-1 as a Marker of Renal Tubular Injury Associated with Urethral Obstruction in Non-Azotemic Cats.

Animals : an open access journal from MDPI·2026
Same author

Electron donating and withdrawing groups affect the antioxidant activity of 4'-aminochalcones on gentamicin-induced kidney cell injury.

Biological chemistry·2026
Same author

Kidney and endothelial injury biomarkers as predictors of complications and mortality in patients with malaria: a systematic review.

Malaria journal·2026
Same author

Role of Serum IL-33 in <i>Bothrops</i> Snakebite Victims: Linking Inflammation and Endothelial Dysfunction.

Toxins·2026
Same author

Incidence and Severe Outcomes of Acute Kidney Injury in Haff Disease: A Brazilian Cohort Study.

Tropical medicine & international health : TM & IH·2026

Related Experiment Video

Updated: Feb 10, 2026

Direct Drug Delivery to Kidney via the Renal Artery
11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

8.3K

Renal Evaluation in Common Variable Immunodeficiency.

Giovany Gomes Capistrano1, Gdayllon Cavalcante Meneses2, Fernanda Macedo de Oliveira Neves1

  • 1Medical Sciences Postgraduate Program, Department of Clinical Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.

Journal of Immunology Research
|May 9, 2018
PubMed
Summary
This summary is machine-generated.

Common variable immunodeficiency (CVID) patients often exhibit impaired kidney tubular function, specifically in urinary acidification and concentration. This study highlights a trend towards elevated tubular dysfunction in CVID, emphasizing the need for further renal assessment.

More Related Videos

Bioengineering Human Microvascular Networks in Immunodeficient Mice
06:55

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Published on: July 11, 2011

12.8K
Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
08:38

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

Published on: August 28, 2013

26.2K

Related Experiment Videos

Last Updated: Feb 10, 2026

Direct Drug Delivery to Kidney via the Renal Artery
11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

8.3K
Bioengineering Human Microvascular Networks in Immunodeficient Mice
06:55

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Published on: July 11, 2011

12.8K
Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
08:38

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

Published on: August 28, 2013

26.2K

Area of Science:

  • Nephrology
  • Immunology
  • Internal Medicine

Background:

  • Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by impaired antibody production.
  • Kidney involvement in CVID is infrequently reported, often in isolated case studies.
  • Understanding renal function patterns in CVID is crucial for comprehensive patient management.

Purpose of the Study:

  • To investigate renal function in CVID patients using glomerular and tubular tests.
  • To assess glomerular filtration rate (GFR) and markers of glomerular barrier selectivity.
  • To evaluate tubular function, including urinary concentration and acidification capacities.

Main Methods:

  • Compared 12 CVID patients with 12 healthy controls.
  • Measured GFR, fractional excretion of sodium and potassium, and urinary concentration capacity.
  • Assessed urinary acidification capacity, microalbuminuria, and urinary monocyte chemoattractant protein-1 (MCP-1).

Main Results:

  • CVID patients maintained normal GFR, with similar microalbuminuria and urinary MCP-1 levels compared to controls.
  • A significant reduction in urinary concentration capacity was observed in CVID patients (lower U/POsm ratio).
  • Impaired urinary acidification capacity was evident in CVID patients, who failed to lower urinary pH below 5.3 after acid loading.

Conclusions:

  • CVID patients demonstrate a tendency towards impaired tubular dysfunction.
  • The primary tubular defects identified relate to reduced urinary acidification and concentration capacities.
  • These findings suggest a potential for subclinical renal tubular abnormalities in CVID patients.