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Adipokine-myokine-hepatokine compartment-system in mothers and children: An explorative study

Clara Deibert1, Nina Ferrari2, Anne Flöck3

  • 1University of Cologne Medical School, Joseph-Stelzmann-Straße 20, 50931 Cologne, Germany.

Contemporary Clinical Trials Communications
|May 9, 2018
PubMed

Insights

Maternal lifestyle choices impact pregnancy outcomes. This study explores how different lifestyle patterns influence maternal and fetal health markers, including body composition and birth weight.

Area of Science:

  • Reproductive biology and maternal-fetal medicine.
  • Endocrinology and metabolic health.
  • Nutritional science and public health.

Background:

  • Maternal overweight and excessive gestational weight gain increase risks for pregnancy complications and neonatal metabolic issues.
  • Adipokines, hepatokines, and myokines from fat, liver, and muscle tissues are implicated in metabolic homeostasis, but their link to maternal lifestyle is unclear.
  • Understanding lifestyle's role in modulating these biomarkers is crucial for improving maternal and fetal outcomes.

Purpose of the Study:

  • To investigate the influence of maternal lifestyle clusters during pregnancy on maternal and fetal biomarkers.
  • To examine the association between maternal lifestyle, body composition, and birth weight.
  • To explore the role of adipokines, hepatokines, and myokines in this complex interplay.

Main Methods:

  • An exploratory pilot study including at least 100 singleton pregnancies.
  • Collection of maternal anthropometric data, blood samples, physical activity, and nutritional status via questionnaires.
  • Assessment of newborn anthropometrics, umbilical cord samples, and birth outcomes, alongside measurement of key biomarkers.

Main Results:

  • This section is to be filled once the study is completed and results are available.

Conclusions:

  • This study pioneers the examination of maternal body composition, birth weight, and related biomarkers using a novel compartment model.
  • Findings will elucidate the intricate relationship between maternal lifestyle, metabolic biomarkers, and fetal development.
Abstract

Keywords:
Birth weightBody compositionMaternal cytokinesMaternal lifestyleNeonatal cytokinesPregnancy

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