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Related Concept Videos

Amino acids03:42

Amino acids

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Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...
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Polyprotic Acids03:38

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Acids are classified by the number of protons per molecule that they can give up in a reaction. Acids such as HCl, HNO3, and HCN that contain one ionizable hydrogen atom in each molecule are called monoprotic acids. Their reactions with water are:
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Mixtures of Acids03:27

Mixtures of Acids

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The pH of a solution containing an acid can be determined using its acid dissociation constant and its initial concentration. If a solution contains two different acids, then its pH can be determined using one of several methods depending upon the relative strength of the acids and their dissociation constants.
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In a mixture of a strong acid and a weak acid, the strong acid dissociates completely and becomes a source of almost all the hydronium ions...
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Nucleic Acids02:43

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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Carboxylic acids are the strongest organic acids. However, their acidic strength is much less than mineral acids like HCl. Carboxylic acids ionize in water and readily lose the hydroxyl proton to form a resonance-stabilized carboxylate ion.
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Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
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Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

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Hyaluronic Acid.

Hélder Pereira1,2,3,4,5, Duarte Andre Sousa6, António Cunha7

  • 13B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal. helderduartepereira@gmail.com.

Advances in Experimental Medicine and Biology
|May 9, 2018
PubMed
Summary

Tissue engineering and regenerative medicine (TERM) offers new orthopedic treatments. This review focuses on hyaluronic acid (HA) and other orthobiologics for musculoskeletal tissue regeneration.

Keywords:
Growth factorsHyaluronic acidOrthobiologicsOsteochondral lesionsPlatelet-rich plasmaStem cellsTendinopathiesTissue engineering and regenerative medicine

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Area of Science:

  • Orthopedics
  • Tissue Engineering and Regenerative Medicine (TERM)
  • Biomaterials Science

Background:

  • The field of tissue engineering and regenerative medicine (TERM) has advanced therapeutic strategies for orthopedic applications.
  • However, TERM approaches require careful consideration of biological responses and bioactive agents, with some products showing limited clinical success.
  • Orthobiologics, including biomaterials, stem cells, and growth factors, represent a growing trend for musculoskeletal tissue improvement.

Purpose of the Study:

  • To overview recent clinical studies on hyaluronic acid (HA) for orthopedic conditions like osteochondral lesions and tendinopathies.
  • To briefly discuss the potential of combining different orthobiologic agents for TERM clinical strategies in orthopedics.

Main Methods:

  • Literature review of recent clinical studies focusing on hyaluronic acid (HA) in orthopedic treatments.
  • Discussion of the synergistic potential between biologic therapies and surgical interventions.
  • Exploration of combined orthobiologic agents for regenerative medicine strategies.

Main Results:

  • Hyaluronic acid (HA) has shown promise in treating various orthopedic conditions.
  • Evidence-based approaches in orthobiologics can lead to considerable clinical success when expectations are realistic.
  • The combination of different orthobiologic agents presents potential for enhanced TERM strategies.

Conclusions:

  • Hyaluronic acid (HA) is a key orthobiologic agent with therapeutic potential in orthopedics.
  • A serious, evidence-based approach to TERM and orthobiologics is crucial for successful clinical outcomes.
  • Combining various orthobiologic agents may offer advanced, synergistic solutions for orthopedic regeneration.