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A Quantitative Systems Pharmacology Approach to Infer Pathways Involved in Complex Disease Phenotypes.

Mark E Schurdak1, Fen Pei2, Timothy R Lezon2

  • 1Department of Computational and Systems Biology, University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, USA. Mes234@pitt.edu.

Methods in Molecular Biology (Clifton, N.J.)
|May 9, 2018
PubMed
Summary

Quantitative systems pharmacology (QSP) integrates computational and experimental methods to uncover disease pathways. This approach aids in developing precision medicine strategies for complex diseases like Huntington's disease by analyzing compound effects on cellular phenotypes.

Keywords:
ChemogenomicsHeterogeneityHuntington’s diseasePHIPittsburgh Heterogeneity IndexPrecision medicineQSPQuantitative systems pharmacology

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Area of Science:

  • Computational biology
  • Pharmacology
  • Systems biology

Background:

  • Precision medicine faces challenges in treating complex diseases due to intricate gene product interactions.
  • Targeting single molecular entities often lacks clinical efficacy for diseases like cancer and neurodegeneration.
  • A systems-level understanding of disease progression is crucial for optimizing therapeutic strategies.

Purpose of the Study:

  • To present the chemogenomic component of Quantitative Systems Pharmacology (QSP) for inferring biological pathways.
  • To demonstrate how QSP can elucidate pathways involved in modulating disease phenotypes.
  • To apply this approach to monogenic Huntington's disease (HD) as a model for complex diseases.

Main Methods:

  • Testing diverse compound sets with known mechanisms of action in disease-relevant phenotypic assays.
  • Utilizing mechanistic information of active compounds to infer associated biological pathways and networks.
  • Applying the chemogenomic QSP approach to Huntington's disease, a monogenic disorder with complex pathogenesis.

Main Results:

  • The chemogenomic QSP approach successfully infers biological pathways linked to disease phenotypes.
  • This method provides a systems-level understanding of molecular pathogenesis.
  • Demonstrated applicability to Huntington's disease, highlighting its potential for complex diseases.

Conclusions:

  • Quantitative Systems Pharmacology offers a comprehensive approach to drug discovery for complex diseases.
  • The chemogenomic component of QSP is effective in inferring disease-associated pathways and networks.
  • This strategy holds promise for developing more effective precision medicine interventions for a range of complex conditions.