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Bioreactors for Cardiac Tissue Engineering.

Jesus Paez-Mayorga1, Gustavo Hernández-Vargas2, Guillermo U Ruiz-Esparza3,4

  • 1Tecnologico de Monterrey, School of Medicine and Health Sciences, Ave. Eugenio Garza Sada 2501, Monterrey, N. L., CP 64849, Mexico.

Advanced Healthcare Materials
|May 9, 2018
PubMed
Summary
This summary is machine-generated.

Biotechnology advances enable engineered cardiac tissues to mimic native heart function, addressing heart disease and donor shortages. Bioreactor systems are key to recapitulating cardiac microenvironments for functional and preclinical applications.

Keywords:
bioreactorscardiac diseasescardiac tissue engineeringelectrical stimulationmechanical stimulationtissue engineeringvascularization

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Area of Science:

  • Biotechnology
  • Biomaterials
  • Biomechanics
  • Tissue Engineering

Background:

  • Heart disease is a leading cause of mortality.
  • Current treatments and organ transplantation face limitations.
  • Novel solutions are needed for cardiac repair and regeneration.

Purpose of the Study:

  • To review biotechnological advances in cardiac tissue engineering.
  • To focus on the role of bioreactors in recreating cardiac tissue microenvironments.
  • To discuss functional and preclinical applications of engineered cardiac constructs.

Main Methods:

  • Review of current literature on cardiac tissue engineering.
  • Analysis of bioreactor systems for cardiac tissue development.
  • Examination of functional and preclinical studies of engineered cardiac constructs.

Main Results:

  • Engineered cardiac tissues can emulate natural heart function.
  • Bioreactors are crucial for recapitulating cardiac tissue microenvironments.
  • Functional and preclinical applications demonstrate therapeutic potential.

Conclusions:

  • Cardiac tissue engineering offers promising solutions for heart disease.
  • Bioreactor technology is advancing the field towards clinical translation.
  • Future research should focus on clinical translation and scalability.