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Updated: Feb 10, 2026
08:22
Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
Published on: August 11, 2017
16.4K
Microfluidics-Enabled Multimaterial Maskless Stereolithographic Bioprinting
Amir K Miri1,2, Daniel Nieto1,2,3, Luis Iglesias1,2
1Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Advanced Materials (Deerfield Beach, Fla.)
|May 9, 2018
Summary
This study introduces a stereolithography bioprinting platform for creating complex, multimaterial hydrogel constructs. The system enables high-resolution, layer-by-layer fabrication for tissue engineering and regenerative medicine applications.
Area of Science:
- Biotechnology
- Materials Science
- Regenerative Medicine
Background:
- Conventional stereolithography struggles with multimaterial fabrication.
- High-resolution patterning of heterogeneous hydrogels is crucial for advanced tissue engineering.
Purpose of the Study:
- To develop a stereolithography-based bioprinting platform for multimaterial hydrogel construct fabrication.
- To demonstrate high spatial resolution and biocompatibility for tissue engineering applications.
Main Methods:
- Utilized a digital micromirror device for dynamic patterning.
- Integrated a novel microfluidic device with pneumatic valves for rapid bioink switching.
- Fabricated constructs using poly(ethylene glycol) diacrylate (PEGDA) and gelatin methacryloyl (GelMA).
Main Results:
- Achieved layer-by-layer multimaterial bioprinting with high spatial resolution.
- Demonstrated biocompatibility through fabrication of cellularized constructs.
- Assessed neovascularization potential of patterned hydrogels in a rat model.
Conclusions:
- The developed platform enables on-demand, high-fidelity multimaterial bioprinting.
- This system offers advantages over conventional methods for tissue engineering, regenerative medicine, and biosensing.
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