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[Analysis of Pathogens and Clinical Characteristics in 157 Cases with Infective Endocarditis]
Fei-Fei Zhao1, Yang Lu1, Hui Ye1
1Center of Infectious Diseases,West China Hospital,Sichuan University,Chengdu 610041,China.
Objective:
To analyze the clinical characteristics of infective endocarditis (IE) in culture-positive patients,so as to provide the evidences for reasonable diagnosis and treatment of IE.
Methods:
We performed a retrospective study of 157 culture-positive IE cases,which were diagnosed according to modified Duke criteria for IE from Jan. 2008 to Aug. 2015.
Results:
The average age of 157 cases of IE was 40.85 years. One hundred and one patients (64.3%) had various underlying cardiac diseases,including congenital cardiovascular diseases in 44 cases and rheumatic heart diseases in 15 cases. The main clinical manifestations were anemia (147 cases,93.6%),fever(137 cases,87.3%) and heart murmur (120 cases,76.4%). Vegetation was found in 12 cases (7.6%) with transesophageal echocardiography (TEE) but not with transthoracic echocardiography (TTE) . Culture results showed the most common causative microorganisms were Streptococci (76 cases,48.4%),with Viridans streptococci dominated in 70 cases,and Staphylococci (33 cases,21.0%) (Staphylococcus aureus dominated in 18 cases). All patients were treated with antimicrobial agents. Eighty-five patients (54.1%) received surgical intervention,of which 72 cases received valve replacement. Twenty-seven patients were cured,88 patients were markedly improved,38 patients discontinued treatment,and 4 patients died. The therapeutic efficacy of operation group was better.
Conclusion:
The clinical characteristics of IE included: the age of onset increased,congenital heart disease was the most underlying disease,and Viridians streptococci was the most popular causative microorganism. Surgical therapy can effectively improve the outcomes of IE patients.
Insights
Infective endocarditis (IE) in culture-positive patients shows increasing age at onset, with congenital heart disease as a common underlying condition. Surgical therapy significantly improves outcomes for IE patients.
Area of Science:
- Cardiology
- Infectious Diseases
- Clinical Medicine
Background:
- Infective endocarditis (IE) is a serious infection affecting heart valves and surfaces.
- Understanding the clinical profile of culture-positive IE is crucial for effective management.
Purpose of the Study:
- To analyze the clinical characteristics of culture-positive infective endocarditis (IE).
- To provide evidence-based insights for the diagnosis and treatment of IE.
Main Methods:
- Retrospective study of 157 culture-positive IE cases diagnosed between January 2008 and August 2015.
- Cases were diagnosed using modified Duke criteria for IE.
Main Results:
- The average age of patients was 40.85 years, with 64.3% having underlying cardiac diseases, predominantly congenital cardiovascular diseases.
- Common clinical manifestations included anemia (93.6%), fever (87.3%), and heart murmur (76.4%).
- Streptococci (48.4%), particularly Viridans streptococci, and Staphylococci (21.0%) were the most common causative microorganisms. Surgical intervention improved outcomes.
Conclusions:
- The clinical characteristics of IE involve an increasing age of onset and congenital heart disease as a primary underlying condition.
- Viridans streptococci emerged as the most prevalent causative microorganism.
- Surgical therapy demonstrated effectiveness in improving patient outcomes for IE.
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