Rhodium-Catalyzed Highly Regioselective and Stereoselective Intermolecular Hydrosilylation of Internal Ynamides under
Nan Zheng1,2, Wangze Song1, Tiexin Zhang1
1State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology , Dalian University of Technology , Dalian 116024 , P. R. China.
Abstract:
A rhodium-catalyzed highly regio- and stereoselective intermolecular hydrosilylation of internal ynamides has been developed. With the neutral rhodium complex [Rh(CO)2Cl]2 as a catalyst and the bulky silanes as reactants, various ynamides underwent hydrosilylation smoothly at room temperature with an excellent β-regioselectivity and anti-stereoselectivity. The synthetically versatile β-silyl ( Z)-enamide products could be further transformed to diverse useful building blocks. Several possible mechanisms are proposed to rationalize this unique formal trans-addition-type selectivity.
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