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Collection of Post-mating Semen from the Female Reproductive Tract and Measurement of Semen Liquefaction in Mice
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Thyroid dysfunction and semen quality.

Sandro La Vignera1, Roberto Vita2

  • 11 Department of Clinical and Experimental Medicine, Policlinico "G. Rodolico," University of Catania, Catania, Italy.

International Journal of Immunopathology and Pharmacology
|May 9, 2018
PubMed
Summary
This summary is machine-generated.

Thyroid hormone imbalances, both excess (hyperthyroidism) and deficit (hypothyroidism), negatively impact male fertility by reducing semen quality and sperm parameters. Thyroid function tests are crucial for diagnosing infertility in men.

Keywords:
male infertilitysemen qualitythyroid hormones

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Area of Science:

  • Reproductive Endocrinology
  • Endocrinology
  • Andrology

Background:

  • Thyroid hormones are essential for normal testicular function, influencing Leydig cells, Sertoli cells, and germ cells.
  • Both hyperthyroidism and hypothyroidism can disrupt testicular function, leading to male infertility and abnormal semen parameters.

Discussion:

  • Hyperthyroidism is linked to decreased semen volume, sperm density, motility, and morphology.
  • Hypothyroidism is primarily associated with impaired sperm morphology.
  • Thyroid dysfunction affects sperm production and quality through various cellular mechanisms within the testis.

Key Insights:

  • Thyroid hormone levels directly correlate with male reproductive health and semen quality.
  • Altered thyroid hormone status significantly impacts sperm parameters crucial for fertility.
  • Thyroid function assessment is a vital component of the etiological investigation of male infertility.

Outlook:

  • Further research is needed to fully elucidate the precise mechanisms by which thyroid hormones affect sperm parameters.
  • Investigating therapeutic interventions targeting thyroid dysfunction may offer new avenues for managing male infertility.
  • Standardizing study methodologies in human and murine models will enhance the comparability and impact of future research on thyroid-male fertility interactions.