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Kinetic Measurement and Real Time Visualization of Somatic Reprogramming
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Somatic Cell Reprogramming Informed by the Oocyte.

Elena Gonzalez-Munoz1,2,3, Jose B Cibelli1,4,5

  • 11 LARCEL, Andalusian Laboratory of Cell Reprogramming (LARCel), Andalusian Center for Nanomedicine and Biotechnology-BIONAND , Málaga, Spain .

Stem Cells and Development
|May 9, 2018
PubMed
Summary
This summary is machine-generated.

Somatic cell nuclear transfer (SCNT) and induced pluripotent stem cells (iPSCs) reprogram cells, but oocyte factors offer a more efficient alternative for chromatin remodeling and pluripotency. This review compares these reprogramming methods.

Keywords:
embryonic stem cellsinduced pluripotentnuclear transferoocyte

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Area of Science:

  • Cell biology
  • Developmental biology
  • Stem cell research

Background:

  • Somatic cell nuclear transfer (SCNT) demonstrated oocyte reprogramming capacity and cell plasticity.
  • Induced pluripotent stem cells (iPSCs) using transcription factors became preferred for cell reprogramming due to ease of use.
  • However, iPSC derivation is inefficient and stochastic.

Purpose of the Study:

  • To review the use of oocytes as a source of reprogramming factors.
  • To compare SCNT and iPSC mechanisms for chromatin remodeling and pluripotency acquisition.

Main Methods:

  • Literature review of SCNT and iPSC reprogramming methods.
  • Comparative analysis of chromatin remodeling and pluripotency induction.

Main Results:

  • SCNT showcases potent nuclear reprogramming by oocytes.
  • iPSCs offer a convenient but inefficient reprogramming method.
  • Oocyte factors present a promising alternative for efficient reprogramming.

Conclusions:

  • Oocytes possess unique factors for efficient cell reprogramming.
  • Understanding oocyte-mediated reprogramming can improve iPSC technology.
  • Further research into oocyte factors could enhance stem cell therapies.