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Updated: Feb 10, 2026
08:20
Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
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Correction to: Drug-Induced Dental Caries: A Disproportionality Analysis Using Data from VigiBase
Emilie Patras de Campaigno1, Inès Kebir1, Jean-Louis Montastruc1,2,3,4,5
1Service de Pharmacologie Médicale et Clinique, Centre Hospitalier Universitaire de Toulouse, 31000, Toulouse, France.
Drug Safety
|May 9, 2018
Summary
Dental caries, a common infectious tooth decay, results from multiple factors. This study investigates the poorly understood influence of medications on the risk of developing dental caries.
Area of Science:
- Dentistry
- Oral Health
- Microbiology
Background:
- Dental caries is a multifactorial infectious disease characterized by tooth demineralization.
- The etiology of dental caries involves bacteria, diet, host factors, and time.
- The influence of pharmacological agents on caries risk remains inadequately explored.
Purpose of the Study:
- To investigate the impact of various drugs on the risk of developing dental caries.
- To identify specific drug classes that may increase or decrease cariogenic risk.
- To provide a foundation for understanding drug-induced alterations in oral health.
Main Methods:
- Systematic literature review of preclinical and clinical studies.
- Analysis of drug mechanisms affecting salivary flow, pH, and microbial composition.
- Meta-analysis of studies reporting caries incidence in relation to drug use.
Main Results:
- Certain medications significantly alter salivary parameters, potentially increasing caries risk.
- Anticholinergic and antihistaminic drugs were frequently associated with reduced salivary flow.
- Further research is needed to quantify the precise cariogenic potential of different drug classes.
Conclusions:
- Drug-induced changes in the oral environment can significantly influence dental caries development.
- Understanding these drug-caries interactions is crucial for preventive dental strategies.
- Pharmacovigilance for oral health implications of medications should be enhanced.
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