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Failure of a dengue 1 sub-unit vaccine to protect mice against a lethal dengue virus infection
J G Aaskov1, L Williams, J Fletcher
1Department of Medical Laboratory Science, Queensland Institute of Technology, Brisbane, Australia.
The American Journal of Tropical Medicine and Hygiene
|November 1, 1988
Abstract:
Mice immunized with DEN-1 pre-matrix protein produced antibody which reacted with dengue virus infected cells and intact virions but failed to neutralize virus in vitro or in vivo. Newborn mice passively immunized with anti-DEN-1 pre-matrix antibody also failed to survive intracerebral infection with 100 LD50 of any dengue virus serotype.