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Published on: December 27, 2016
Antiplasmodial Diterpenoids and a Benzotropolone from Petradoria pumila
Yongle Du1, Ana L Valenciano2, Michael Goetz3
1Department of Chemistry and the Virginia Tech Center for Drug Discovery, M/C 0212 , Virginia Tech , Blacksburg , Virginia 24061 , United States.
Abstract:
An extract of Petradoria pumila from the Natural Products Discovery Institute was found to have moderate antiplasmodial activity, with an IC50 value between 5 and 10 μg/mL. The four new diterpenoids petradoriolides A-D (1-4), the new benzotropolone petradoriolone (5), and the two known lignans 6 and 7 were isolated after bioassay-directed fractionation. The structures and stereochemistries of the new compounds were determined by interpretation of NMR spectroscopy, mass spectrometry, and ECD spectra. Among these compounds, petradoriolide C (3) displayed the most potent antiplasmodial activity, with an IC50 value of 7.3 μM.
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