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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
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When analyzing a beam subjected to various loads, it is crucial to understand the internal forces and moments generated within the structure. These internal forces can be broadly classified into normal forces, shear forces, and bending moments. To determine these forces and moments, we use the method of sections and apply a specific sign convention based on their direction and the side of the section being analyzed.
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Trial and Error and Algorithm01:12

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A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
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Related Experiment Video

Updated: Feb 10, 2026

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
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Self-Limiting versus Conventional Caries Removal: A Randomized Clinical Trial.

A H Ali1,2, G Koller1,3,4, F Foschi1,3

  • 11 Conservative & MI Dentistry (including Endodontics), King's College London Dental Institute at Guy's Hospital, King's Health Partners, London, UK.

Journal of Dental Research
|May 9, 2018
PubMed
Summary
This summary is machine-generated.

A self-limiting caries excavation technique using chemomechanical gel and magnification significantly improved pulp survival rates compared to conventional rotary bur methods. This minimally invasive approach offers better outcomes for deep caries treatment.

Keywords:
bacteriaclinical outcomescomputed tomographymicroscopypulpitisradiography

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Area of Science:

  • Restorative Dentistry
  • Caries Management
  • Pulp Biology

Background:

  • Deep caries with reversible pulpitis presents a treatment challenge, balancing complete bacterial removal with pulp preservation.
  • Conventional rotary bur excavation can lead to over-instrumentation and potential pulp exposure.
  • Minimally invasive techniques aim to preserve healthy tooth structure and pulp vitality.

Purpose of the Study:

  • To compare the clinical outcomes of a self-limiting caries excavation protocol versus conventional selective dentin removal.
  • To assess pulp sensibility, periapical health, and bacterial load after 12 months.
  • To evaluate the efficacy of cone beam computed tomography (CBCT) versus periapical radiographs (PAs) in detecting periapical lesions.

Main Methods:

  • A single-blind randomized controlled trial involving 86 patients with deep caries and reversible pulpitis.
  • Intervention: Self-limiting excavation using chemomechanical gel (Carisolv) and operating microscope.
  • Control: Selective removal to leathery dentin using rotary burs, followed by mineral trioxide aggregate (MTA) pulp protection and restoration in a single visit.
  • Assessments included pulp sensibility, periapical health (CBCT/PAs), and bacterial tissue concentration via qPCR at 12 months.

Main Results:

  • No significant difference in bacterial tissue concentration between the self-limiting (96.3% reduction) and control (97.1%) groups.
  • The self-limiting protocol showed a 4-fold higher probability of 12-month success (odds ratio = 4.33) and improved pulp survival rates (90% vs. 73.3%).
  • Molars had a significantly higher probability of success than premolars (odds ratio = 4.17). CBCT detected more periapical lesions than PAs at baseline.

Conclusions:

  • The self-limiting caries excavation protocol significantly increases the pulp survival rate compared to conventional rotary bur excavation.
  • This minimally invasive approach, utilizing chemomechanical agents and magnification, is a viable and effective treatment for deep caries with reversible pulpitis.
  • CBCT is superior to PAs for baseline periapical lesion detection in this patient population.