Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Uncertainty in Measurement: Accuracy and Precision03:37

Uncertainty in Measurement: Accuracy and Precision

104.1K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
104.1K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.2K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.2K
Accuracy and Precision01:52

Accuracy and Precision

15.6K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value.  Highly accurate...
15.6K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.2K
The Precise Definition of a Limit01:27

The Precise Definition of a Limit

325
Understanding the formal definition of a limit is essential for precise mathematical analysis. This concept allows us to rigorously determine how a function behaves near a particular point without relying on ambiguous notions such as "getting close." The ε-δ definition plays a foundational role in calculus, ensuring analytical clarity and logical consistency in limit evaluation.The formal definition states that the limit of a function f(x) as x approaches a is L, written asif for...
325
The Placebo Effect01:54

The Placebo Effect

6.9K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MRD-negativity by PBMCs and ctDNA confirms deep and durable responses following epcoritamab monotherapy in R/R FL.

Blood advances·2026
Same author

Pan-cancer analysis reveals Rho kinase addiction as a vulnerability of de-differentiated cancer cells.

iScience·2026
Same author

Early PET response predicts the risk of relapse after 2L axi-cel in large B-cell lymphoma.

Blood advances·2026
Same author

Case Report: CAR-T therapy for relapsed diffuse large B-cell lymphoma in a patient with pre-existing Parkinson's disease-unfolding clinical challenges.

Frontiers in oncology·2026
Same author

PAIRWISE: Deep Learning-based Prediction of Effective Personalized Drug Combinations in Cancer.

Research square·2026
Same author

Common variation at 1q23.3, 2p23.3, 2q33.3, and 2p21 influences the risk of acute myeloid leukemia.

Blood·2026

Related Experiment Video

Updated: Feb 10, 2026

Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

5.5K

Precision medicine and lymphoma.

James A Heward1, Emil A Kumar, Koorosh Korfi

  • 1Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.

Current Opinion in Hematology
|May 9, 2018
PubMed
Summary

Tailoring treatments for germinal center lymphomas like diffuse large B cell lymphoma (DLBCL) and follicular lymphoma is crucial. Advances in genetic profiling and novel therapies offer personalized strategies for improved patient outcomes.

More Related Videos

Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision
07:57

Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision

Published on: April 29, 2014

14.0K
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K

Related Experiment Videos

Last Updated: Feb 10, 2026

Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

5.5K
Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision
07:57

Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision

Published on: April 29, 2014

14.0K
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K

Area of Science:

  • Hematology
  • Oncology
  • Genomics

Background:

  • Current treatments for germinal center lymphomas, including diffuse large B cell lymphoma (DLBCL) and follicular lymphoma, rely heavily on immunochemotherapies.
  • A significant patient subset requires tailored treatment approaches for improved outcomes.

Purpose of the Study:

  • To review recent advancements in the stratification and therapeutic strategies for germinal center lymphomas.
  • To highlight the potential of precision medicine in managing these hematologic malignancies.

Main Methods:

  • Analysis of recent studies on genetic profiling and risk stratification models (m7-FLIPI, 23G).
  • Review of ongoing clinical trials for novel therapeutic agents, including BCR and EZH2 inhibitors.
  • Exploration of cell-free DNA for dynamic disease monitoring.

Main Results:

  • DLBCL subtypes exhibit distinct genetic heterogeneity and clinical outcomes.
  • Refined risk stratification models improve identification of high-risk patients.
  • BCR and EZH2 inhibitors show promise in specific patient subgroups.
  • Cell-free DNA offers potential for real-time tumor evolution prediction.

Conclusions:

  • Genomic insights provide opportunities for enhanced risk stratification and personalized therapies in germinal center lymphomas.
  • Integrating prognostication with precision therapies presents a challenge for clinical practice and trials.