Related Experiment Video

Updated: Feb 10, 2026

Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease
06:39

Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease

Published on: February 18, 2020

7.2K

Association between interleukin-35 polymorphisms and coronary heart disease in the Chinese Zhuang population: a

Yingzhong Lin, Yan Xue, Xinshun Huang

    Coronary Artery Disease
    |May 9, 2018
    PubMed

    Insights

    The EBI3 rs428253 CC genotype is linked to a higher risk of coronary heart disease (CHD) in the Chinese Zhuang population. This finding suggests a potential genetic marker for CHD susceptibility.

    Area of Science:

    • Genetics
    • Cardiovascular Disease
    • Immunology

    Background:

    • Inflammatory cytokines are implicated in cardiovascular disease pathogenesis.
    • Interleukin-35 (IL-35) is an inflammatory cytokine with a role in immune regulation.
    • Limited research exists on the association between IL-35 genetic variants and coronary heart disease (CHD) risk.

    Purpose of the Study:

    • To investigate the association between IL-35 gene polymorphisms and the risk of developing CHD.
    • To examine specific single nucleotide polymorphisms (SNPs) within the IL-35 gene.
    • To analyze plasma IL-35 levels in relation to identified genotypes.

    Main Methods:

    • A case-control study involving 707 CHD patients and 707 controls from the Chinese Zhuang population.
    • Genotyping of nine IL-35 SNPs (rs428253, rs6613, rs9807813, rs2243115, rs568408, rs582054, rs583911, rs4740, rs393581) using MassArray.
    • Plasma IL-35 levels measured via enzyme-linked immunosorbent assay (ELISA).
    • Multivariate logistic regression analysis applied to assess SNP-CHD risk association.

    Main Results:

    • The EBI3 rs428253 CC genotype showed a significantly higher risk of CHD (OR=2.30, P=0.042) compared to the GG genotype.
    • No statistically significant association was found between SNPs rs4740, rs2243115, rs568408, and rs582054 and CHD risk.
    • Plasma IL-35 levels exhibited a marginally significant difference between rs428253 genotypes (P=0.057).

    Conclusions:

    • The EBI3 rs428253 CC genotype is associated with an increased risk of CHD in the Chinese Zhuang population.
    • This genetic variant may serve as a potential biomarker for CHD susceptibility in this ethnic group.
    • Further research is warranted to elucidate the functional mechanisms underlying this association.
    Abstract

    More Related Videos

    Author Spotlight: Demonstrating Therapeutic Effect of Automated Zhuang Medicine Line Moxibustion Simulator04:35

    Author Spotlight: Demonstrating Therapeutic Effect of Automated Zhuang Medicine Line Moxibustion Simulator

    Published on: January 19, 2024

    1.4K
    Analysis of Coronary Vessels in Cleared Embryonic Hearts08:25

    Analysis of Coronary Vessels in Cleared Embryonic Hearts

    Published on: December 7, 2016

    8.6K

    Related Concept Videos

    Coronary Artery Disease I: Introduction01:30

    Coronary Artery Disease I: Introduction

    Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
    1.2K
    Coronary Artery Disease II: Pathophysiology01:26

    Coronary Artery Disease II: Pathophysiology

    Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
    516
    Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

    Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

    The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
    665
    Coronary Artery Disease V: Interprofessional Care01:27

    Coronary Artery Disease V: Interprofessional Care

    Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
    298
    Conservation of Small Populations02:04

    Conservation of Small Populations

    Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
    17.4K
    Genome-wide Association Studies-GWAS01:11

    Genome-wide Association Studies-GWAS

    Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
    GWAS does not require the identification of the target gene involved in...
    15.8K