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Magnesium Citrate Protects Against Vascular Calcification in an Adenine-induced Chronic Renal Failure Rat Model

Zhihui Yao1, Yang Xu1, Weidong Ma1

  • 1Department of Cardiovascular Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Journal of Cardiovascular Pharmacology
|May 9, 2018
PubMed

Insights

Magnesium citrate (MgCit) helps prevent vascular calcification (VC) in rats with chronic renal failure (CRF). This study suggests MgCit may be a potential therapeutic for preventing VC in CRF patients.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Hypomagnesemia is a significant risk factor for cardiovascular disease in chronic renal failure (CRF) patients.
  • The precise impact of magnesium (Mg) on vascular calcification (VC) in CRF remains unclear.

Purpose of the Study:

  • To investigate the protective effects of magnesium citrate (MgCit) against vascular calcification (VC) in a rat model of chronic renal failure (CRF).

Main Methods:

  • Rats with CRF were induced using adenine and phosphorus, then treated with varying doses of MgCit.
  • Evaluated VC markers including calcium and phosphorus content, alkaline phosphatase activity, and expression of alpha smooth muscle actin and RUNX2 in aortic tissues.

Main Results:

  • The CRF model group exhibited significant VC.
  • MgCit treatment dose-dependently reduced VC, decreasing calcium and phosphorus levels, alkaline phosphatase activity, and RUNX2 expression, while increasing alpha smooth muscle actin.

Conclusions:

  • Magnesium citrate (MgCit) demonstrates a protective effect against vascular calcification (VC) in rats with chronic renal failure (CRF).
  • MgCit shows potential as a therapeutic agent for preventing VC in patients suffering from CRF.
Abstract

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