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Changes of Blood Pressure and Hemodynamic Parameters after Oral Magnesium Supplementation in Patients with Essential

Nikolina Banjanin1, Goran Belojevic2

  • 1Institute of Hygiene and Medical Ecology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia. nikolina.banjanin@med.bg.ac.rs.

Nutrients
|May 9, 2018
PubMed

Insights

Oral magnesium supplementation significantly lowered blood pressure in patients with essential hypertension. This essential mineral intake also reduced systemic vascular resistance and left cardiac work, potentially explaining the blood pressure reduction.

Area of Science:

  • Cardiology
  • Nutritional Science

Background:

  • Essential hypertension is a prevalent condition requiring effective management.
  • Magnesium plays a crucial role in cardiovascular health and vascular tone regulation.

Purpose of the Study:

  • To investigate the impact of oral magnesium supplementation on blood pressure and hemodynamic parameters in individuals with essential hypertension.
  • To determine if magnesium supplementation alters key cardiovascular indicators.

Main Methods:

  • A single-arm, non-blinded study involving 48 patients with essential hypertension.
  • Participants received 300 mg of oral magnesium oxide daily for one month.
  • Blood pressure and hemodynamic parameters were measured using impedance cardiography before and after supplementation.

Main Results:

  • Significant reductions in both systolic (139.7 to 130.8 mmHg) and diastolic blood pressure (88.0 to 82.2 mmHg) were observed (p < 0.001).
  • Key hemodynamic changes included a decrease in systemic vascular resistance index and left cardiac work index (p < 0.05).

Conclusions:

  • Daily oral magnesium supplementation effectively lowers blood pressure in patients with essential hypertension.
  • The observed reductions in systemic vascular resistance and left cardiac work index may underlie the antihypertensive effects of magnesium.

Keywords:
cardiac outputdietary supplementshypertensionmagnesiumsystemic vascular resistance

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