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Updated: Feb 10, 2026
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Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
Published on: December 24, 2013
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Donepezil for Compulsive Behavior in Degenerative Dementia: Case Series
Biswa Ranjan Mishra1, Vanteemar S Sreeraj2, Saranya Dhanashekaran2
1Department of Psychiatry, All India Institute of medical Sciences, Bhuvaneshwar, India.
Summary
Diagnosing dementia with compulsions is difficult. Cholinergic modulation may help manage compulsive behaviors in dementia patients who respond to Donepezil.
Area of Science:
- Neuroscience
- Geriatric Medicine
- Pharmacology
Background:
- Dementia diagnosis and management, particularly with compulsive behaviors, presents significant clinical challenges.
- Compulsive symptoms in dementia can be difficult to manage and may indicate specific underlying neuropathology.
Observation:
- Three cases of dementia patients exhibiting compulsive behaviors and responding to Donepezil treatment are presented.
- These cases may represent a subset of individuals who benefit from acetylcholinesterase inhibitor therapy.
Findings:
- Selective degeneration of the dorsolateral prefrontal cortex networking the striatum is hypothesized to underlie these compulsions.
- This specific neurodegenerative pattern suggests a potential neurobiological basis for compulsive symptoms in dementia.
Implications:
- Cholinergic modulation, as achieved with Donepezil, may be an effective strategy for managing compulsions in specific dementia subtypes.
- Understanding the neuroanatomical correlates of compulsive behaviors can guide targeted therapeutic interventions and improve patient outcomes.
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