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Relapsed/refractory thrombotic thrombocytopenic purpura treated with N-acetylcysteine: a case report
Sinan Demircioğlu1, Ömer Ekinci1, Ali Doğan1
1Department of Hematology, Van Yüzüncü Yil University, Turkey.
Abstract:
Thrombotic thrombocytopenic purpura is a rare condition that presents with microangiopathic haemolytic anaemia, thrombocytopaenia, fever, renal impairment and neurological symptoms. Plasma exchange is a lifesaving treatment for this condition. However, some cases may be non-responsive to plasma exchange, or loss of response may occur. Treatment options for refractory cases include high-dose corticosteroids, rituximab, vincristine, cyclophosphamide, splenectomy, bortezomib and N-acetylcysteine. We present a refractory case of thrombotic thrombocytopenic purpura responding to the last of these therapies.
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