Related Experiment Video
Updated: Feb 10, 2026

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis
Published on: August 9, 2024
Re-irradiation in lung disease by SBRT: a retrospective, single institutional study
Donatella Caivano1, Maurizio Valeriani2, Sara De Matteis2
1Departement of Radiation Oncology, CNAO (National Centre of Oncological Hadrontherapy), Str. Campeggi, 53, 27100, Pavia, Italy. donatella.caivano@gmail.com.
Background:
The loco regional relapse is frequent in the lung disease. The aim of this study was to evaluate the outcomes of re-irradiation by SBRT in terms of Local Control (LC) and toxicities.
Methods:
From April 2011 to December 2016, twenty-two patients received a re-irradiation by SBRT. Twenty- seven lesions were treated. The medium BED(10) of re-irradiation was 100.6 Gy (range: 48-151.2 Gy) and the medium EQD2(10) was 93.8 Gy (range: 40-126 Gy). In the previous treatment the medium BED(10) was 97.2 Gy (range: 40-120 Gy), the medium EQD2(10) was 81 Gy (range: 32.5-100 Gy). The median time between the first and the second treatment was 18 months.
Results:
Local Control was reached in 18 out of 27 (66%) re-irradiated lesions, with rates of 67 and 54% at 1- year and 2- years respectively. The treatment was well tolerated; the maximum recorded toxicity was Grade 3.
Conclusions:
Re- irradiation by SBRT may represent an option for the treatment of lung disease with good results in terms of LC and toxicity.
Related Concept Videos
Lung Capacity
Bioavailability Study Design: Single Versus Multiple Dose Studies
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Pleura of the Lungs

