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Early identification of epileptic encephalopathy with continuous spikes-and-waves during sleep: A case-control study

Camille Desprairies1, Blandine Dozières-Puyravel2, Adina Ilea2

  • 1AP-HP, Hôpital Robert Debré, Service de Neurologie Pédiatrique, 75019, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, INSERM UMR1141, 75019, Paris, France.

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
|May 10, 2018
PubMed

Insights

Early recognition of epileptic encephalopathy with continuous spikes-and-waves during sleep (EE-CSWS) is crucial. However, no specific clinical or EEG signs predict EE-CSWS after the first seizure.

Area of Science:

  • Pediatric Neurology
  • Epileptology
  • Clinical Neurophysiology

Background:

  • Epileptic encephalopathy with continuous spikes-and-waves during sleep (EE-CSWS) is a rare childhood epilepsy.
  • EE-CSWS presents with cognitive, behavioral, and psychiatric decline, seizures, and characteristic EEG patterns.
  • Early diagnosis and treatment are vital for improving outcomes in EE-CSWS.

Purpose of the Study:

  • To investigate early clinical and electroencephalographic (EEG) indicators of EE-CSWS following the initial seizure.
  • To determine if predictive signs exist for EE-CSWS development after a first seizure.

Main Methods:

  • A retrospective case-control study was conducted.
  • Ten EE-CSWS patients with initial EEG recordings were matched with ten control patients.
  • EEG recordings from the first seizure were analyzed for predictive features.

Main Results:

  • No specific clinical or EEG features at the time of the first seizure were found to predict the later development of EE-CSWS.
  • Cases showed a higher frequency of multiple seizure types and seizure worsening during follow-up compared to controls.

Conclusions:

  • Predictive clinical or EEG markers for EE-CSWS are not identifiable at the time of the first seizure.
  • Multiple seizure types and worsening seizures may serve as clinical red flags for identifying potential EE-CSWS cases.

Keywords:
Case-control studyContinuous spikes and waves in sleepEpilepsyEpileptic encephalopathy

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