Related Experiment Video

Updated: Feb 10, 2026

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
10:37

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice

Published on: January 16, 2015

13.7K

Neonatal outcomes of extremely preterm infants exposed to maternal hypertension and cigarette smoking

Kamran Yusuf1, Belal Alshaikh2, Orlando da Silva3

  • 1Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. kyusuf@ucalgary.ca.

Journal of Perinatology : Official Journal of the California Perinatal Association
|May 10, 2018
PubMed

Insights

Maternal hypertension increases the risk of bronchopulmonary dysplasia in extremely preterm infants, regardless of smoking. Smoking during pregnancy was linked to lower odds of maternal hypertension.

Area of Science:

  • Neonatal Intensive Care
  • Perinatal Epidemiology
  • Maternal-Fetal Medicine

Background:

  • Extremely preterm infants face significant health risks.
  • Maternal health conditions like hypertension and smoking can impact neonatal outcomes.
  • Understanding these combined effects is crucial for improving infant care.

Purpose of the Study:

  • To investigate the neonatal outcomes of extremely preterm infants born to mothers with hypertension, considering maternal smoking status.
  • To compare outcomes between infants of hypertensive smokers, hypertensive non-smokers, normotensive smokers, and normotensive non-smokers.

Main Methods:

  • Retrospective cohort study of infants born <29 weeks' gestation (2003-2012) from the Canadian Neonatal Network.
  • Infants categorized into four groups based on maternal hypertension and smoking status.
  • Neonatal outcomes analyzed using univariate and multivariate regression, with infants of normotensive, non-smoking mothers as the reference group.

Main Results:

  • Infants of hypertensive mothers, irrespective of smoking, had higher odds of bronchopulmonary dysplasia (AORs 1.62 and 1.43).
  • No significant differences in mortality or severe retinopathy of prematurity were observed between groups.
  • Maternal smoking was associated with decreased odds of hypertension (AOR 0.71).

Conclusions:

  • Maternal hypertension is a significant risk factor for bronchopulmonary dysplasia in extremely preterm infants, independent of smoking.
  • The study highlights the complex interplay between maternal hypertension, smoking, and neonatal outcomes.
  • Further research may explore targeted interventions for high-risk pregnancies.
Abstract

More Related Videos

Transcutaneous Microcirculatory Imaging in Preterm Neonates06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

8.6K
Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System10:44

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System

Published on: May 24, 2017

12.2K

Related Concept Videos

Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
11.0K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.6K
Absolute and Local Extreme Values01:22

Absolute and Local Extreme Values

The highest and lowest values of a function, relative to a reference axis, are known as extreme values. These include absolute maximum and absolute minimum values, which represent the highest and lowest points the function reaches across its entire domain. Within a restricted portion of the function, the highest and lowest values are referred to as local maximum and local minimum values, respectively.Periodic functions, such as sine and cosine, show extreme values at infinitely many points due...
86
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
953
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.0K
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
482