High-efficient extraction of principal medicinal components from fresh Phellodendron bark (cortex phellodendri)
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Updated: Feb 10, 2026

Extraction of the EPP Component from the Surface EMG
Published on: December 16, 2009
Keqin Xu1, Gongxiu He1, Jieming Qin1
1Key Laboratory of Cultivation and Protection for Non-Wood Forest Trees (Ministry of Education) & Hunan Provincial Key Laboratory of Forestry Biotechnology, Central South University of Forestry and Technology, Changsha 410004, China.
Abstract:
There are three key medicinal components (phellodendrine, berberine and palmatine) in the extracts of Phellodendron bark, as one of the fundamental herbs of traditional Chinese medicine. Different extraction methods and solvent combinations were investigated to obtain the optimal technologies for high-efficient extraction of these medicinal components.
Results:
The results showed that combined solvents have higher extracting effect of phellodendrine, berberine and palmatine than single solvent, and the effect of ultrasonic extraction is distinctly better than those of distillation and soxhlet extraction.
Conclusion:
The hydrochloric acid/methanol-ultrasonic extraction has the best effect for three medicinal components of fresh Phellodendron bark, providing an extraction yield of 103.12 mg/g berberine, 24.41 mg/g phellodendrine, 1.25 mg/g palmatine.
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