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Whole Brain Functional Connectivity Pattern Homogeneity Mapping.

Lijie Wang1,2, Jinping Xu3, Chao Wang4

  • 1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.

Frontiers in Human Neuroscience
|May 10, 2018
PubMed
Summary
This summary is machine-generated.

A new method, functional connectivity homogeneity (FcHo), measures voxel-wise similarity in brain connectivity patterns. This reliable approach aids in understanding brain organization and identifying disorders.

Keywords:
Kendall’s coefficient concordancefMRIsimilarityvoxel-wisewhole brain functional connectivity

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Area of Science:

  • Neuroscience
  • Brain Imaging
  • Functional Connectivity Analysis

Background:

  • Brain function is intrinsically linked to its external functional connectivity patterns.
  • Characterizing voxel-wise similarity across the entire brain's functional connectivity remains a challenge.
  • Existing methods may not fully capture the nuanced spatial relationships of connectivity.

Purpose of the Study:

  • To introduce and validate a novel method, functional connectivity homogeneity (FcHo), for assessing voxel-wise similarity in whole-brain functional connectivity.
  • To evaluate the robustness and reliability of the FcHo method across diverse datasets.
  • To compare FcHo with existing methods like local regional homogeneity (ReHo) and demonstrate its application in distinguishing cognitive states.

Main Methods:

  • Developed functional connectivity homogeneity (FcHo) by measuring voxel similarity with nearest neighbors (26, 18, 6) using Kendall's coefficient concordance (KCC).
  • Validated FcHo robustness using four independent MRI datasets and intra-subject reproducibility.
  • Compared FcHo distribution with local regional homogeneity (ReHo) and applied FcHo to differentiate brain patterns between professional Chinese chess players and novices.

Main Results:

  • FcHo mapping consistently showed high homogeneity in association cortices (parietal, frontal, occipital lobes, default mode network) and low homogeneity in unimodal cortices (visual, sensorimotor areas).
  • Results were robust across different neighbor counts (26, 18, 6) and demonstrated good intra-subject reproducibility.
  • FcHo revealed distinct patterns compared to ReHo and successfully identified functional connectivity differences in Chinese chess players versus novices.

Conclusions:

  • FcHo is a reliable and robust method for delineating voxel-wise similarity in whole-brain functional connectivity patterns.
  • FcHo offers a novel approach to studying brain functional organization and may aid in uncovering the neuropathological basis of brain disorders.
  • The method's ability to differentiate cognitive states highlights its potential for clinical and research applications in neuroscience.