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The effect of atrial natriuretic factor on urinary albumin and beta 2-microglobulin excretion in man
J McMurray1, P H Seidelin, J E Howey
1Department of Clinical Pharmacology, Ninewells Hospital, Medical School, Dundee, Scotland, UK.
Journal of Hypertension
|October 1, 1988
Abstract:
The effect of a 20-min infusion of atrial natriuretic factor (ANF) 99-126, 0.4 microgram/kg per min, on both urinary albumin and beta 2-microglobulin excretion was examined in nine normal male subjects during stable water diuresis. ANF caused a rise in urinary albumin in excretion (from 4.19 +/- 0.66 to 13.49 +/- 3.07 ng/min, P less than 0.01) without any significant change in either creatinine clearance of beta 2-microglobulin excretion. These findings suggest that ANF may enhance glomerular permeability to albumin in man.