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Circulating Survivin Levels in Obstructive Sleep Apnoea.

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Plasma survivin levels are lower in patients with obstructive sleep apnoea (OSA), indicating potential immune dysregulation. This finding suggests survivin may play a role in OSA pathogenesis and inflammation.

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Area of Science:

  • Immunology
  • Sleep Medicine
  • Biochemistry

Background:

  • Obstructive sleep apnoea (OSA) is linked to systemic and airway inflammation, but regulatory mechanisms remain unclear.
  • Survivin (Birc5), an anti-apoptotic protein, is known to inhibit Type 1 inflammation and has not been previously studied in OSA.

Purpose of the Study:

  • To investigate plasma survivin levels in patients with OSA compared to non-OSA controls.
  • To explore the relationship between survivin levels, OSA severity, and associated comorbidities.

Main Methods:

  • Collected venous blood from 45 OSA patients and 31 controls for plasma survivin measurement.
  • Measured survivin levels before and after polysomnography.
  • Correlated survivin levels with OSA severity indices and clinical parameters.

Main Results:

  • Plasma survivin levels were significantly lower in OSA patients both in the evening and morning compared to controls.
  • Lower survivin levels in OSA correlated with increased apnoea-hypopnoea index and oxygen desaturation index, though these relationships diminished after adjusting for BMI.
  • Reduced survivin concentrations were associated with higher BMI, C-reactive protein (CRP), and triglyceride levels, and lower HDL cholesterol.

Conclusions:

  • Plasma survivin levels are reduced in OSA and correlate with disease severity and inflammatory markers like CRP.
  • These findings suggest impaired immunoregulation in OSA.
  • Further research is warranted to elucidate the role of survivin in OSA pathophysiology.