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Updated: Feb 10, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
A comparison of ventricular systolic function indices provided by VolumeView/EV1000™ and left ventricular ejection
Nitchakan Nakwan1, Ply Chichareon2, Bodin Khwannimit3,4
1Division of Critical Care Medicine, Department of Internal Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
Insights
Cardiac Function Index (CFI) and Global Ejection Fraction (GEF) measured by VolumeView/EV1000™ reliably estimate Left Ventricular Ejection Fraction (LVEF) in septic shock patients. These indices show strong correlation and predictive ability for assessing LV systolic function.
Area of Science:
- Critical Care Medicine
- Cardiology
- Hemodynamics
Background:
- Septic shock poses significant challenges in assessing cardiac function.
- Accurate monitoring of left ventricular systolic function is crucial for patient management.
- Echocardiography is a standard but sometimes limited method for evaluating ejection fraction.
Purpose of the Study:
- To compare Cardiac Function Index (CFI) and Global Ejection Fraction (GEF) from VolumeView/EV1000™ with Left Ventricular Ejection Fraction (LVEF) by echocardiography.
- To evaluate the correlation between CFI, GEF, and LVEF in septic shock patients.
- To assess the predictive ability of CFI and GEF for different LVEF thresholds.
Main Methods:
- Prospective observational study in a medical intensive care unit.
- Inclusion of 32 mechanically ventilated septic shock patients.
- Simultaneous measurement of CFI, GEF (VolumeView/EV1000™), and LVEF (echocardiography).
Main Results:
- Strong correlation found between CFI and GEF (r=0.82, P<0.0001).
- Significant correlations observed between CFI and LVEF (r=0.56, P<0.0001) and GEF and LVEF (r=0.71, P<0.0001).
- CFI and GEF demonstrated good predictive ability for LVEF thresholds (AUC 0.875-0.934).
Conclusions:
- CFI and GEF obtained by VolumeView/EV1000™ correlate well with LVEF.
- These indices provide a reliable estimation of left ventricular systolic function in septic shock.
- CFI and GEF are valuable tools for monitoring cardiac function in critically ill patients.
Abstract:
The aim of this study was to compare the cardiac function index (CFI) and global ejection fraction (GEF) obtained by VolumeView/EV1000™, with the left ventricular ejection fraction (LVEF) by echocardiography in septic shock patients. A prospective observational study was conducted in a medical intensive care unit of a tertiary, teaching university hospital. Thirty-two, mechanical-ventilated septic shock patients were included in this study. We simultaneously measured CFI and GEF with LVEF. The correlation of CFI, GEF along with LVEF and ability of CFI and GEF to predict LVEF ≥ 40, 50 and 60% were evaluated. There were 192 pairs of CFI, GEF and LVEF. CFI was significantly correlated with GEF (r = 0.82, P < 0.0001). A significant correlation was observed between CFI and LVEF (r = 0.56, P < 0.0001) and GEF and LVEF (r = 0.71, P < 0.0001). The CFI and GEF had a good predictive ability for estimating LVEF ≥ 40, 50 and 60%, with an area under receiving operating characteristic (AUC) 0.875-0.934. The CFI ≥ 3/min predicted LVEF ≥ 40% with sensitivity 95.1% and specificity 48.3%. The GEF ≥ 15%, estimated LVEF ≥ 40% with sensitivity 92.6% and specificity 69%. There were 40 thermodilution and LVEF measurements obtained before and after norepinephrine adjustment. Blood pressure as well as the cardiac index were significantly increased, whereas there were no changes in CFI, GEF and LVEF values. Conclusions: Both CFI and GEF obtained by VolumeView/EV1000™, correlated with LVEF, so as to provide a reliable estimation of LV systolic function in septic shock patients.
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