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Association between male accesory gland infections and prostate cancer in Turkish men: A case-control study

S Aykan1, M Z Temiz2, M Yilmaz1

  • 1Department of Urology, Bagcilar Training and Research Hospital, Istanbul, Turkey.

Andrologia
|May 10, 2018
PubMed

Insights

Male accessory gland infections (MAGI) significantly increase prostate cancer risk. This study found MAGI in 58% of prostate cancer patients, compared to 22% of controls, suggesting a link to high-grade tumors.

Area of Science:

  • Urology
  • Oncology
  • Pathology

Background:

  • Chronic inflammation is a known risk factor for various cancers.
  • Previous research explored prostatitis and prostate cancer links.
  • A gap exists in understanding male accessory gland infections (MAGI) and prostate cancer co-occurrence.

Purpose of the Study:

  • To investigate the association between male accessory gland infections (MAGI) and prostate cancer in Turkish men.
  • To determine if MAGI is a risk factor for prostate cancer development.
  • To explore the relationship between MAGI and prostate cancer grade.

Main Methods:

  • A case-control study was conducted with 155 male patients.
  • Patients were categorized into control and prostate cancer groups based on prostate biopsy pathology.
  • Male accessory gland infections (MAGI) were diagnosed through pathological examination of biopsy specimens.

Main Results:

  • Of 145 eligible patients, MAGI was diagnosed in 58.06% of the prostate cancer group (18/31) versus 21.93% in the control group (25/114) (p=0.001).
  • A significant correlation was found between MAGI and pathological Gleason score (p=0.0001).
  • Prostate cancers in this population were predominantly clinically significant or high-grade.

Conclusions:

  • Male accessory gland infections (MAGI) are associated with an increased risk of developing prostate cancer.
  • MAGI may be linked to higher-grade prostate cancer.
  • Further research is warranted to elucidate the mechanisms behind this association.
Keywords:
maleprostate cancerreproductive tract infections

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