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New trends and applications in carboxylation for isotope chemistry
Ryan A Bragg1, Malvika Sardana2, Markus Artelsmair2
1Isotope Chemistry, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
Abstract:
Carboxylations are an important method for the incorporation of isotopically labeled 14 CO2 into molecules. This manuscript will review labeled carboxylations since 2010 and will present a perspective on the potential of recent unlabeled methodology for labeled carboxylations. The perspective portion of the manuscript is broken into 3 major sections based on product type, arylcarboxylic acids, benzylcarboxylic acids, and alkyl carboxylic acids, and each of those sections is further subdivided by substrate.
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