Related Experiment Video
Updated: Feb 10, 2026

Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
Eversion endarterectomy of the deceased donor renal artery to prevent kidney discard
Muhammad A Khan1, Hany El-Hennawy1, Korie C Jones1
1Department of Surgery, Section of Transplantation, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Introduction:
Deceased donor (DD) kidneys exhibiting severe atherosclerosis involving the renal artery (RA) may represent a contraindication to kidney transplantation (KT).
Methods:
Eversion endarterectomy (EE) was performed as a salvage procedure to permit KT.
Results:
We identified 17 cases (1.2% of all DD KTs during the study period) involving EE of the DD RA. Thirteen (76.5%) kidneys were imported, and mean Kidney Donor Profile Index (KDPI) was 81%. Mean DD age was 59 years, mean RA plaque length was 1.7 cm, and mean glomerulosclerosis on biopsy was 10%. Mean recipient age was 64 years, and dialysis vintage was 32 months. With a mean follow-up of 36 months, actual patient and graft survival rates were both 76.5%. One patient died early without a technical problem. Of the remaining 16 patients, 2-year patient and graft survival rates were both 100%. There were no early or late vascular complications. The incidence of delayed graft function was 35%. Mean serum creatinine and GFR levels in patients with functioning grafts at latest follow-up were 1.8 mg/dL and 40 mL/min, respectively.
Conclusions:
EE appears to be a safe and under-utilized procedure that may prevent discard of marginal donor kidneys and is associated with acceptable short-term outcomes.
Related Concept Videos
Kidney Structure
Coronary Artery Disease IV: Preventive Measures
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Cancer Prevention
Some...
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Prevention of Further Absorption of Poison

