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Preventive effect of nicorandil on contrast-induced nephropathy: a meta-analysis of randomised controlled trials

Shuang Li1, Lin Wang2, Yucai Liu1

  • 1Department of Pharmacy, LinYi Central Hospital, Linyi, China.

Internal Medicine Journal
|May 10, 2018
PubMed

Insights

Nicorandil significantly reduces contrast-induced nephropathy (CIN) by 64% in patients undergoing contrast procedures. This medication offers a protective effect on renal function, presenting a new option for CIN prevention.

Area of Science:

  • Nephrology
  • Cardiology
  • Radiology

Background:

  • Contrast-induced nephropathy (CIN) is a significant complication following angiocardiography and radiological procedures.
  • Effective preventative strategies for CIN are crucial for patient safety and outcomes.

Purpose of the Study:

  • To comprehensively evaluate the efficacy of nicorandil in preventing contrast-induced nephropathy (CIN).
  • To synthesize existing data on nicorandil's impact on renal function markers post-contrast exposure.

Main Methods:

  • A systematic literature search was conducted across Medline/PubMed, EMBASE, and Cochrane Central Register of Controlled Trials up to April 2017.
  • Four randomized controlled trials (RCTs) with a total of 730 participants were included in the meta-analysis.

Main Results:

  • Nicorandil demonstrated a significant 64% reduction in the incidence of CIN compared to control groups (Risk Ratio = 0.36, 95% CI: 0.22-0.61).
  • Treatment with nicorandil led to a significant decrease in serum creatinine levels.
  • A non-significant trend towards reduced cystatin C levels was observed with nicorandil use.

Conclusions:

  • Nicorandil effectively protects renal function and lowers the incidence of CIN in patients receiving contrast media.
  • Nicorandil represents a valuable additional therapeutic option for the prevention of contrast-induced nephropathy.
Abstract

Keywords:
angiocardiographycontrast mediumkidney diseasenicorandil

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