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Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Nucleophilic Reactivities of Bleach Reagents
Robert J Mayer1, Armin R Ofial1
1Department Chemie , Ludwig-Maximilians-Universität München , Butenandtstraße 5-13 , 81377 München , Germany.
Abstract:
The nucleophilicities of the oxidants hydroperoxide, hypochlorite, hypobromite, bromite, and peroxymonosulfate were determined by following the kinetics of their reactions with a series of benzhydrylium ions of known electrophilicity ( E) in alkaline, aqueous solutions at 20 °C. The reactivities of the oxidants correlate only weakly with their basicities. Analyzing the rate constants by using the relationship log k2 = sN( N + E) gave the parameters N (and sN), which were applied to predict the rates of Weitz-Scheffer epoxidations.
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