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Updated: Feb 10, 2026

Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis
Published on: August 1, 2019
Overexpression of Fn14 in gliomas: tumor progression and poor prognosis
Dan Tan1,2,3,4, Feng-Mei Pang1,2,3,4, Dan Li1,2,3,4
1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China.
Aim:
To confirm whether the expression level of Fn14 could affect progression or prognosis of glioma patients.
Methods:
Glioma cohorts in The Cancer Genome Atlas, Gene Expression Omnibus and Chinese Glioma Genome Atlas databases were comprehensively analyzed.
Results:
Low-grade patients had lower expression level of Fn14, while patients with higher expression of Fn14 tended to harbor shorter overall survival and disease-free survival. The expression level of Fn14 was downregulated by IDH1/IDH2 mutations while its gene body methylation was upregulated. After adjusting age, the expression level of Fn14 was still significantly associated with overall survival and disease-free survival in low-grade gliomas. In a cell line data analysis, Fn14 expression was positively correlated with temozolomide dosage.
Conclusion:
Fn14 was an independent predictive biomarker for the progression and prognosis in low-grade gliomas.
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