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Updated: Feb 10, 2026
10:09
Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes
Published on: September 13, 2022
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Checkpoint inhibition in lymphoma.
Gunjan L Shah1, Craig H Moskowitz2
1Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Clinical Advances in Hematology & Oncology : H&O
|May 10, 2018
Summary
Checkpoint inhibitors enhance immune surveillance, improving outcomes in certain lymphoma subtypes. Research is exploring their use across different treatment lines, including upfront and relapsed/refractory settings.
Area of Science:
- Oncology
- Immunology
- Hematology
Background:
- Checkpoint inhibitors activate the immune system to target cancer cells.
- Their efficacy in lymphoma is increasingly recognized, particularly in relapsed/refractory disease.
Purpose of the Study:
- To review current evidence on checkpoint inhibition in lymphoma based on treatment line.
- To discuss ongoing research and future directions for these therapies.
Main Methods:
- Review of published studies and ongoing clinical trials.
- Analysis of data concerning specific lymphoma subtypes and treatment settings.
Main Results:
- Approved agents (nivolumab, pembrolizumab) for relapsed/refractory Hodgkin lymphoma.
- Investigational use of other PD-1/PD-L1 antibodies as single agents or combinations.
- Biomarkers like 9p24.1 amplification are key for personalized therapy.
Conclusions:
- Checkpoint inhibitors show promise with high response rates and durable remissions in lymphoma.
- Further trials will expand therapeutic options, but immune-related adverse events and transplant complications require management.
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