Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hybrid Zones02:29

Hybrid Zones

22.0K
Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
22.0K
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

429
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
429
Hybridization of Atomic Orbitals I03:24

Hybridization of Atomic Orbitals I

67.7K
The mathematical expression known as the wave function, ψ, contains information about each orbital and the wavelike properties of electrons in an isolated atom. When atoms are bound together in a molecule, the wave functions combine to produce new mathematical descriptions that have different shapes. This process of combining the wave functions for atomic orbitals is called hybridization and is mathematically accomplished by the linear combination of atomic orbitals. The new orbitals that...
67.7K
Hybridization of Atomic Orbitals II03:35

Hybridization of Atomic Orbitals II

49.2K
sp3d and sp3d 2 Hybridization
49.2K
Protein Complex Assembly02:41

Protein Complex Assembly

16.8K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.8K
Design Example: Alignment of a Road Line Using GIS01:17

Design Example: Alignment of a Road Line Using GIS

352
The alignment of a road line using Geographic Information Systems (GIS) is a critical process in civil engineering, combining advanced technology with practical decision-making. This methodology begins with the collection of geospatial data, including information on land cover, geomorphology, drainage patterns, slope, and contour details. Such data is typically acquired through satellite imagery and GIS tools, offering a comprehensive understanding of the terrain.Once the data is gathered, it...
352

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptional regulatory network analysis identifies conserved cis-antisense ncRNAs in the vancomycin and ceftriaxone stress response of <i>Enterococcus faecalis</i>.

Frontiers in molecular biosciences·2026
Same author

From parasite biology to predictive metabolic models.

Trends in parasitology·2026
Same author

Interpretable sentiment-aware transformer-based model for individual log anomaly detection in distributed systems using word-level explanations.

Scientific reports·2026
Same author

MiR-21-5p Protects Embryonic Growth and Heart Function During Developmental Hypoxia by Dampening HIF Responses and Altering Gene Expression.

Comprehensive Physiology·2026
Same author

Transcriptional regulatory network analysis uncovers modular gene control and potential key regulators in diabetic cardiomyopathy.

Frontiers in cell and developmental biology·2026
Same author

Evolutionary computation for reconstructing threshold networks of the tryptophan operon in Escherichia coli.

Bio Systems·2025
Same journal

NanoporeDB: A Structural Resource Of Multimeric Protein Nanopores For Single-Molecule Sensing.

GigaScience·2026
Same journal

From the Brain Cell Atlas to Precision Neurology: A review of the application of AI-driven multi-omics in brain science.

GigaScience·2026
Same journal

Comparison of Deep Learning Approaches for Extreme Low-SNR Image Restoration.

GigaScience·2026
Same journal

ScopeViewer: A Browser-Based Solution for Visualizing Large Biological Images.

GigaScience·2026
Same journal

ChatMDV: Reducing Technical Barriers in Bioinformatics Analysis using Large Language Models.

GigaScience·2026
Same journal

ClusterGraph: a new tool for visualisation and compression of multidimensional data.

GigaScience·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Assembly, Loading, and Alignment of an Analytical Ultracentrifuge Sample Cell
11:36

Assembly, Loading, and Alignment of an Analytical Ultracentrifuge Sample Cell

Published on: November 5, 2009

23.2K

Fast-SG: an alignment-free algorithm for hybrid assembly.

Alex Di Genova1,2,3,4,5, Gonzalo A Ruz1,6, Marie-France Sagot3,4

  • 1Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez, Santiago, Chile.

Gigascience
|May 10, 2018
PubMed
Summary
This summary is machine-generated.

Fast-SG is a new method for genome assembly that uses an ultrafast, alignment-free algorithm. This approach enables accurate, long-range genome reconstructions with reduced computational resources and cost.

More Related Videos

Self-Assembly of Hybrid Lipid Membranes Doped with Hydrophobic Organic Molecules at the Water/Air Interface
06:28

Self-Assembly of Hybrid Lipid Membranes Doped with Hydrophobic Organic Molecules at the Water/Air Interface

Published on: May 1, 2020

4.0K
Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
12:08

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies

Published on: August 20, 2021

5.8K

Related Experiment Videos

Last Updated: Feb 10, 2026

Assembly, Loading, and Alignment of an Analytical Ultracentrifuge Sample Cell
11:36

Assembly, Loading, and Alignment of an Analytical Ultracentrifuge Sample Cell

Published on: November 5, 2009

23.2K
Self-Assembly of Hybrid Lipid Membranes Doped with Hydrophobic Organic Molecules at the Water/Air Interface
06:28

Self-Assembly of Hybrid Lipid Membranes Doped with Hydrophobic Organic Molecules at the Water/Air Interface

Published on: May 1, 2020

4.0K
Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
12:08

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies

Published on: August 20, 2021

5.8K

Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • Long-read sequencing offers high accuracy for reconstructing large genomes, particularly repetitive regions.
  • However, de novo assembly using long reads is computationally demanding and requires substantial data coverage.
  • Hybrid assembly methods combining short and long reads present a cost-effective alternative for large genome assembly.

Purpose of the Study:

  • To introduce Fast-SG, an ultrafast, alignment-free algorithm for constructing scaffolding graphs.
  • To enable modular hybrid assembly pipelines by leveraging efficient short-read algorithms.
  • To demonstrate the effectiveness of Fast-SG for both short and long-read data.

Main Methods:

  • Developed Fast-SG, an alignment-free algorithm utilizing lightweight data structures for scaffolding graph construction.
  • Applied Fast-SG to both raw and error-corrected long reads for linking information extraction.
  • Implemented a hybrid assembly pipeline using Fast-SG with shallow long-read coverage (5X).

Main Results:

  • Fast-SG demonstrates superior performance over state-of-the-art short-read aligners in scaffolding graph construction.
  • The method successfully extracts linking information from various long-read types.
  • Hybrid assembly with Fast-SG achieved accurate, long-range genome reconstructions for Arabidopsis thaliana and human (NA12878) using minimal resources.

Conclusions:

  • Fast-SG facilitates accurate, hybrid, long-range genome reconstructions of large genomes.
  • The method offers low computational effort, high portability, and cost-effectiveness.
  • Enables broader application of advanced genome assembly techniques.