Related Experiment Video
Updated: Feb 10, 2026
06:41
Minimizing Post-Infusion Portal Vein Bleeding during Intrahepatic Islet Transplantation in Mice
Published on: May 10, 2021
4.4K
Management of post-transplant lymphoproliferative disorders
Christin B DeStefano1, Sanjal H Desai1, Aarthi G Shenoy1
1Department of Hematology, MedStar Washington Hospital Center, Washington, DC, USA.
British Journal of Haematology
|May 10, 2018
Summary
Post-transplant lymphoproliferative disorders (PTLDs) are serious transplant complications. Management balances PTLD eradication with risks like graft rejection, using conventional and novel therapies.
Area of Science:
- Oncology
- Immunology
- Transplantation Medicine
Background:
- Post-transplant lymphoproliferative disorders (PTLDs) are rare but severe complications following solid organ and bone marrow transplantation.
- Optimal treatment strategies are limited due to the rarity of PTLDs, necessitating careful management.
- Balancing PTLD eradication with risks such as graft rejection and infection is a significant clinical challenge.
Purpose of the Study:
- To provide a comprehensive review of PTLD management in solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients.
- To discuss the challenges in managing PTLDs, considering the delicate balance of immunosuppression and treatment efficacy.
- To explore emerging therapeutic approaches, including novel agents, for improved PTLD outcomes.
Main Methods:
- Comprehensive literature review focusing on PTLD management post-SOT and HSCT.
- Analysis of current treatment paradigms and their associated risks and benefits.
- Review of ongoing clinical trials investigating novel therapeutic agents for PTLD.
Main Results:
- PTLD management requires a nuanced approach due to its heterogeneity and rarity.
- Conventional therapies must be carefully balanced against the risk of graft rejection and other complications.
- Novel agents show promise in clinical trials, potentially enhancing current treatment strategies.
Conclusions:
- Effective PTLD management is critical for improving patient outcomes after transplantation.
- A combination of conventional and novel therapies may offer improved PTLD eradication rates.
- Further research and clinical trials are essential to refine treatment protocols for PTLDs.
Related Concept Videos
01:27Post-traumatic Stress Disorder
579
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
579
01:16Kidney Transplant III: Nursing Management
405
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
405
01:28Cardiomyopathy VII: Pre and Post Operative Nursing Management
372
Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
372
02:18Intrinsically Disordered Proteins
19.6K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.6K
01:29Bone Disorders
5.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.5K
01:27Disorders of Erythrocytes
2.3K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.3K