The Effect of Different Intraabdominal Pressures on Thiol/Disulfide Homeostasis in Children Who Underwent Ambulatory

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Seyda Efsun Ozgunay1, Yasemin Ustundag2, Derya Karasu1

  • 11 Department of Anaesthesiology and Reanimation, University of Health Sciences, Yuksek Ihtisas Training and Research Hospital, University of Health Sciences , Bursa, Turkey .

Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
|May 10, 2018
PubMed

Insights

Pediatric laparoscopic surgery with 8 or 12 mm Hg intra-abdominal pressure (IAP) did not alter thiol/disulfide homeostasis. However, 12 mm Hg IAP significantly increased ischemia-modified albumin (IMA) levels, indicating potential oxidative stress.

Area of Science:

  • Biochemistry
  • Surgical Physiology
  • Pediatric Surgery

Background:

  • Thiol/disulfide homeostasis is crucial for assessing oxidative stress post-ischemia and reperfusion.
  • Intra-abdominal pressure (IAP) during laparoscopic surgery may impact oxidative stress markers.

Purpose of the Study:

  • To evaluate the impact of different IAP levels (8 vs. 12 mm Hg) on thiol/disulfide homeostasis and ischemia-modified albumin (IMA) levels in pediatric laparoscopic surgery.
  • To assess hemodynamic changes associated with varying IAP during pediatric laparoscopic procedures.

Main Methods:

  • A study involving 36 pediatric patients undergoing laparoscopic surgery for nonpalpable testis or varicocele.
  • Patients were divided into two groups: 8 mm Hg IAP (n=18) and 12 mm Hg IAP (n=18).
  • Blood samples were collected pre- and post-desufflation to measure thiol/disulfide and IMA levels.

Main Results:

  • No significant changes in thiol/disulfide homeostasis parameters were observed in either the 8 mm Hg or 12 mm Hg IAP groups.
  • A statistically significant increase in serum ischemia-modified albumin (IMA) levels was noted in the 12 mm Hg IAP group post-desufflation (P=0.031).
  • Perioperative heart rate and SpO2 levels showed no statistically significant differences between groups or time points.

Conclusions:

  • Neither 8 mm Hg nor 12 mm Hg IAP significantly affected thiol/disulfide homeostasis indicators in pediatric laparoscopic surgery.
  • Elevated IMA levels at 12 mm Hg IAP suggest a potential increase in oxidative stress at this pressure.
  • Further research is warranted to fully understand the implications of IAP on oxidative stress in pediatric laparoscopic procedures.
Abstract

Keywords:
abdominal pressurehemodynamicslaparoscopythiol-disulfide

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