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Facial Basal Cell Carcinoma in Patients Younger Than 40

Ardeshir Edward Nadimi, Yizhao Zhou, Jaeil Ahn

    Journal of Drugs in Dermatology : JDD
    |May 10, 2018
    PubMed

    Insights

    Younger individuals under 40 have increased odds of developing basal cell carcinoma (BCC) on the forehead. This study highlights potential differences in BCC development and natural history in younger populations.

    Area of Science:

    • Dermatology
    • Oncology
    • Epidemiology

    Background:

    • Basal cell carcinoma (BCC) incidence is increasing in individuals under 40.
    • Most BCCs occur on the head and neck.
    • Forehead and its subunits are common sites for BCC.

    Purpose of the Study:

    • To investigate if BCCs occur more frequently on the forehead and its subunits in patients younger than 40.
    • To analyze BCC distribution in relation to age and sex.

    Main Methods:

    • Retrospective case review of 4,337 BCCs from 3,223 patients.
    • Patients treated with Mohs micrographic surgery were analyzed.

    Main Results:

    • Patients under 40 had a 2.2-fold increased odds of developing BCC on the forehead.
    • Increased odds for forehead proper (2.5x) and temple (2.0x) were observed in younger patients.
    • Females had higher odds for glabella BCC (3.8x) but lower odds for temple BCC.

    Conclusions:

    • Potential underlying differences in BCC pathogenesis and natural history exist in younger populations and between sexes.
    • Lifestyle factors may also contribute to BCC development patterns.
    • Further research is warranted to understand these demographic variations.
    Abstract

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